Exosomes have exhibited promising results in the diagnosis and treatment of cancer, cardiovascular diseases and others. They are a rapidly growing class of drug delivery vehicles with many advantages over conventional synthetic carriers. Exosomes used in therapeutic applications encounter several challenges,...
Resistance to drug therapy is a major impediment for successful treatment of patients suffering from breast cancer (BC). Tamoxifen (TAM) is an extensively used therapeutic agent, which substantially reduces the risk of recurrence and associated mortality in BC. This study demonstrated that exosomal tr...
A total of 128 genes were differentially expressed upon treatment (false discovery rate (FDR) P<0.05). Relatively subtle changes in gene expression were observed (Fig. 7a); however, the most strongly downregulated gene was Dusp1 (also known as MKP-1 in human), a key regulator of MAPK ...
how TM cells and SCE cells interact remains unclear. In this study, we hypothesized that the kind of exomiRs present depends on the status of TM cells, normal or glaucomatous/mesenchymal, and examined which miRNA is a key regulator of SCE cells. ...
Diabetic wound healing is associated with a higher risk of infection, vascular damage, hyperactivation of inflammation, oxidative stress, and persistent failure to heal, thus constituting a current dilemma in skin disease treatment [173]. In addition, exosomes are considered an upgraded version of ste...
For ARS treatment, MSC-EVs have been shown to rescue murine marrow hematopoietic cells after sublethal radiation [30]. Moreover, the contents of MSC-EVs are not static and can be altered by MSC exposure to different stimuli. A recent study indicated that MSCs primed with bacterial LPS, a ...
Consequently, we showed that the effect of MM-derived exosomes on osteoclast differentiation was inhibited by the pre-treatment of exosomes with anti-AREG mAb. In addition, we demonstrated the ability of MM-derived AREG-enriched exosomes to be internalized into human mesenchymal stromal cells (...
[2,39,40]. To study the role of AFsHPi-Exos in the development of vascular calcification in mice with CRF, the mice were randomly divided into four treatment groups (n = 5 per group): Sham group (Sham-operated group fed with high phosphorus diet only), 5/6 NTP group (5/6 ...
Identifying the exosomal surface protein involved in initiating the cardioprotective effects may provide a novel target for the treatment of dystrophin-deficient cardiomyopathy. Studies to identify this protein are underway. In summary, this study demonstrates that acute exposure of endogenous cardiomyocyte-...
10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet 374, 1677–1686 (2009). Hawley, J. A. Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance. Diabetes Metab. Res. Rev. 20, 383–393 (...