Exosomes, being enriched with tumor antigens, have numerous immunomodulatory effects. Much to our intrigue, in recent times, efforts have been directed toward developing smart, bioengineered, exosome-liposome hybrid nanovesicles, which are augmented by the benefits of both vesicular systems. This review...
As an essential carrier of intercellular substance transfer and signal transduction, exosomes with different biological functions can be secreted by various types of cells. There remains significant uncertainty regarding the clinical relevance of exosomes to OME, especially in its pathophysiologic development...
In this review, we examine clinical trials of MSC-derived exosomes currently in progress for gene delivery, regenerative medicine, and immunomodulation. In addition, we summarize the limitations and clinical potential of this cell-free therapeutic strategy....
Immunologic memory, a property of the immune system, plays a crucial role in the effectiveness of cancer vaccines. This memory allows the immune system to recognize and attack cancer cells even after the initial exposure to a cancer vaccine. Unlike other types of immunotherapies, cancer vaccines o...
- 《Regenerative Engineering & Translational Medicine》 被引量: 0发表: 2022年 Exosome-functionalized magnesium-organic framework-based scaffoldswith osteogenic, angiogenic and anti-inflammatory properties foraccelerated bone regenera... Exosomes derived from human adipose-derived stem cells (hADSCs-Exos) ...
Lower back pain alone is the leading cause of years lived with disability worldwide. Despite limited treatment options, regenerative medicine, particularly extracellular vesicles (EVs) and exosomes, holds early promise for patients who have exhausted other treatment options. EVs, including exosomes, are...
The negative effects of MSC-based cell therapy have heightened interest in the therapeutic use of MSC-derived secretome. On the other hand, MSC-derived exosomes and microvesicles possess the potential to have a significant impact on disease development, including cancer. MSCs can interact with tumor...
In contrast, exosomes originate from endosomes and multivesicular bodies (MVBs) and are approximately 40–200 nm in diameter [16,27,85]. The whole formation process of exosomes is highly intricate: initially, inward budding endocytosis gives rise to early endosomes, which subsequently mature into la...
Microfluidic Raman biochip detection of exosomes: a promising tool for prostate cancer diagnosis. Lab Chip 20, 4632–4637 (2020). Article CAS Google Scholar Machtinger, R., Laurent, L. C. & Baccarelli, A. A. Extracellular vesicles: roles in gamete maturation, fertilization and embryo ...
Lung cancer is one of the most common malignant tumours worldwide. however, emerging immunotherapy and targeted therapies continue to show limited efficacy. In the search for new targets for lung cancer treatment, exosomes have become a major focus of re