近日,一篇名为“Exosome-derived tRNA fragments tRF-GluCTC-0005 promotes pancreatic cancer liver metastasis by activating hepatic stellate cells”的论文证实了外泌体衍生的tRNA片段tRF-GluCTC-0005通过激活肝星状细胞促进胰腺癌肝转移。 胰腺导管腺癌(PDAC)是一种极具致死性的实体瘤,其生存率低下,死亡率较高。...
Exosomes are derived from nearly all types of cells and exist in all body fluids. Noncoding RNAs (ncRNAs) are among the most abundant contents in exosomes, and some ncRNAs with biological functions are specifically packaged into exosomes. Recent studies have revealed that exosome-derived ncRNAs ...
Exosome-derived circUPF2 enhances resistance to targeted therapy by redeploying ferroptosis sensitivity in hepatocellular carcinomaFeng-Lin Dong, Zong-Zhen Xu, Ying-Qiao Wang, Tao Li, Xin Wang & Jie Li Journal of Nanobiotechnology volume 22, Article number: 298 (2024) Cite this article ...
ASchematic diagram of diverse PDAC cell lines-derived exosome promoting liver fibrosis in mice. 40ug PDAC-exo was treated in mice every 3 days and all the mice were executed after 3 weeks.BThe degree of liver fibrosis was shown in Masson staining.CThe fluorescence intensity of α-SMA (green...
Exosome-derived circKIF20B suppresses gefitinib resistance and cell proliferation in non-small cell lung cancer Si-Liang Wei, Jing-Jing Ye, Li Sun, Lei Hu, Yuan-Yuan Wei, Da-Wei Zhang, Meng-Meng Xu & Guang-He Fei Cancer Cell International volume 23, Article number: 129 (2023...
However, the pleiotropic functions of exosome-derived miRNAs on developing chemoresistance remain unknown. In the present study, we aimed to construct potential networks of miRNAs, which derived from the exosome of chemoresistant prostate cancer (PCa) cells, with their known target genes using miRNA ...
Tumor-associated macrophages (TAMs), one of the most abundant immune cell types in the tumor microenvironment (TME), account for approximately 50% of the local hematopoietic cells. TAMs play an important role in tumorigenesis and tumor development throug
Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma Zongqiang Hu, Gang Chen, Yingpeng Zhao, Hongqiang Gao, Laibang Li, Yanfeng Yin, Jie Jiang, Li Wang, Yuanyi Mang, Yang Gao, Shengning Zhang, Jianghua Ran & ...
Exosome-derived miRs as circulating biomarkers in cancer Exosomal miR (exo-miR) profiling of serum from cancer patients versus healthy individuals has revealed important differences in relation to tumor progression, highlighting a possible use of these miRs as disease prognostic biomarkers.101 Exosomes ar...
Exosome-derived miRNAs and cellular miRNAs activate innate immunity. Circulating exosome-containing small RNAs have been demonstrated in vitro to be taken up by recipient cells and to alter gene expression through RNA interf... A Mobergslien,M Sioud - 《Journal of Innate Immunity》 被引量: 24...