1. 外泌体衍生物的类型 外泌体膜涂层(Exosome-Coated Nanoparticles):将外泌体膜包裹纳米颗粒(如金纳米颗粒、PLGA 纳米粒),提高其稳定性与靶向性。 外泌体膜片段(Exosome-Derived Membranes):通过超声破碎外泌体,制备成纳米片或纳米囊泡,用于药物递送或免疫调控。 外泌体仿生纳米载体(Exosome-Mimetic Vesicles, ...
近日,一篇名为“Exosome-derived tRNA fragments tRF-GluCTC-0005 promotes pancreatic cancer liver metastasis by activating hepatic stellate cells”的论文证实了外泌体衍生的tRNA片段tRF-GluCTC-0005通过激活肝星状细胞促进胰腺癌肝转移。 胰腺导管腺癌(PDAC)是一种极具致死性的实体瘤,其生存率低下,死亡率较高。...
Exosomes are derived from nearly all types of cells and exist in all body fluids. Noncoding RNAs (ncRNAs) are among the most abundant contents in exosomes, and some ncRNAs with biological functions are specifically packaged into exosomes. Recent studies have revealed that exosome-derived ncRNAs ...
Here, we suggest that exosome-derived circCCAR1 is taken in by CD8 + T cells, which further increases the stability of PD1, causes CD8 + T-cell exhaustion and leads to tumor immunosuppression. Notably, HCC cells with high circCCAR1 expression were resistant to anti-PD1 treatment....
alone miRNA or tRF that has yet been identified as an ideal biomarker for the diagnosis of PDAC. Using a single exosome-derived biomolecule as an indicator to diagnose disease is still a challenge. An increased degree of liver fibrosis can significantly contribute to the proportion of liver ...
Exosome-derived circ-001422 promotes tumor-associated macrophage M2 polarization to accelerate the progression of glioma Wenpeng Cao, Zhirui Zeng, JianFei Sun, Yunhua Chen, FaGuang Kuang, Shipeng Luo, Jinzhi Lan & Shan Lei Communications Biology volume 7, Article number: 1504 (2024) ...
Exosome-derived circ_0001785 delays atherogenesis through the ceRNA network mechanism of miR-513a-5p/TGFBR3 Xiao Tong, Xuan Dang, Dongmei Liu, Ning Wang, Miao Li, Jianbin Han, Jinjin Zhao, Yueqing Wang, Meijiao Huang, Yanliang Yang, Yuhang Yang, Weili Wang, Yan Kou & ...
Exosome derived from stem cell: A promising therapeutics for wound healing. Front Pharmacol. 2022;13: 957771. https://doi.org/10.3389/fphar.2022.957771. Article CAS PubMed PubMed Central Google Scholar An Y, Lin S, Tan X, et al. Exosomes from adipose-derived stem cells and application ...
A large proportion of these exosome-related databases and online analysis applications can be used to analyze tumor models; however, few can be used to analyze tumor-associated immune cell-derived exosomes. Studies have increasingly reported not only that tumor cell-derived exosomes can act on the...
Exosome-derived miRs as circulating biomarkers in cancer Exosomal miR (exo-miR) profiling of serum from cancer patients versus healthy individuals has revealed important differences in relation to tumor progression, highlighting a possible use of these miRs as disease prognostic biomarkers.101 Exosomes ar...