今天给大家分享一篇2022年9月发表在Stem Cell Research & Therapy上的文章,题目为“Mesenchymal stem cell-derived exosome-educated macrophages alleviate systemic lupus erythematosus by promoting efferocytosis and recruitment of IL-17...
Indeed, stem cell-derived exosomes have been successfully used to treat cardiovascular disease(CVD), such as AMI, stroke, and pulmonary hypertension, in animal models, and their efficacy has been demonstrated. Therefore, exosome administration may be a promising strategy for the treatment of CVD. ...
. Zhao and his colleague elucidated that exosome derived from cell line in the inflammatory stroke-like conditions, but not on normal condition, can cross brain microvascular endothelial cells (BMECs) through endocytosis and co-localize with endosomes including receptor-mediated transcytosis, lipid raft...
[5] Norooznezhad AH, Yarani R, Payandeh M, et al. Human placental mesenchymal stromal cell-derived exosome-enriched extracellular vesicles for chronic cutaneous graft-versus-host disease: A case report. J Cell Mol Med. 2022;26(2):588-592. [6]Sengupta V, Sengupta S, Lazo A, Woods P, ...
[11,12]. In addition, MSC-derived exosomes (MSC-Exos) can recapitulate the biological potential of MSCs; therefore, they may substitute for cell therapy to achieve cell-free therapy [13,14]. The advantages of exosome utilization, when compared to their cellular counterparts, include a higher ...
相关内容以“Mesenchymal stem cells-derivedexosomes for drug delivery”为题发表在国际著名杂志Stem Cell Research & Therapy (2021, 12:561)上。本文的第一作者为吉林大学第二医院普外科硕士研究生孙尧,通讯作者为吉林大学第二医院普...
whether by disease or a surgeon’s scalpel, respond by inflammatory and regenerative dynamics,14making surgery a perfect arena for stem cell-derived exosome therapy.15Stem cell-derived exosomes inherit similar therapeutic effects from their parental cell of origin, e.g., tissue regeneration, anti-in...
In addition, stem cell-derived exosomes also have been implicated in the diagnosis and prognosis of CVDs. In this review, we summarize the current advances of stem cell-derived exosome-based treatment and prognosis for CVDs, including their potential benefits, underlying mechanisms and limitations, ...
‘trash bags’ for cells to discard unwanted proteins. However, over the past decade, they have emerged as an important intercellular communication vehicle for modulating or mediating a variety of cellular processes. Exosome release is currently considered an integral mechanism of cell-to-cell ...
Exosomes derived from mesenchymal stem cells. Int J Mol Sci. 2014;15:4142–57. Article CAS PubMed PubMed Central Google Scholar Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, et al. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 2010;4:...