间充质干细胞(mesenchymal stem cell,MSC)源性外泌体(MSC derived exosome,MSC-Exo)是由MSC通过旁分泌作用产生的携带大量生物信息传播介质和活性物质的脂质双分子层包裹纳米级囊泡,可实现有选择性、定向性的细胞间信号转导,抑制炎症反应,促进受损组织的修复与再生。此文就MSC-Exo的生物学特性、作用机制及其在常见疾...
DC-derived exosome,DCex 外泌体miRNAs 环磷酰胺联合树突状细胞分泌的外泌体 MSCs-derived exosomes,MEX 人源肝细胞HepG2外泌体 胰腺β细胞外泌体 HPV阳性头颈部鳞状细胞外泌体 人脐带间充质干细胞来源的外泌体 小胶质细胞外泌体 人骨髓间充质干细胞(BM-MSC)来源的外泌体 大鼠骨髓间充质干细...
MSC-derived exosomal lncRNA SNHG7 suppresses endothelial-mesenchymal transition and tube formation in diabetic retinopathy via miR-34a-5p/XBP1 axisDiabetic retinopathySNHG7miR-34a-5pXBP1ExosomeMesenchymal stem cellsAims Diabetic retinopathy (DR) is the most common complication of type 2 diabetes ...
We found that exosomes derived from MSCs protected hair cells from neomycin-induced damage and promoted autophagy. Mechanistically, exosomes promoted the expression of endocytic genes and the formation of endosomes, which are required for exosome-induced autophagy activation, thereby rescuing the loss of...
外泌体(exosome)是多种细胞分泌的膜外小囊泡,直径30 ~ 200nm,可以转运核酸、脂质和蛋白质,参与细胞间的信息交流。 与MSCs 相比,外泌体用于临床疾病的治疗更加稳定,体内同种异体给药后免疫排斥反应的可能性较低,并可为各种疾病提供替代疗...
MSC-ex Mesenchymal stem cell-derived exosome. PBS Phosphate-buffered saline. ROS Reactive oxygen species. DCF, 2',7' Dichlorofluorescein. GPX4 Glutathione peroxidase 4. ferroptosis inhibitors NAC addition (Supplemental Fig. 1A–C). In addition, transmission electron microscopy images of mitochon- dr...
According to reported difference in the outcome of MSC therapies in GvHD patients,3 we assumed that the exosome preparations from different MSCs might differ in their immune-modulating activities. Hence, MSCs of four different unrelated bone marrow donors were raised initially. The MSC nature of exp...
[2] Ti D, Hao H, Fu X, Han W. Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation. Sci China Life Sci 2016; 59:1305–12. [3] Li X, Liu L, Yang J, Yu Y, Chai J, Wang L, et al. Exosome derived from human umbilical cord mesenchymal stem cell media...
Exosome secretion: molecular mechanisms and roles in immune responses. Traffic. 2011;12:1659–68. Article CAS Google Scholar Nakamura Y, Miyaki S, Ishitobi H, Matsuyama S, Nakasa T, Kamei N, Akimoto T, Higashi Y, Ochi M. Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle ...
MSC-derived exosomes have been shown to repair tissue damage by transferring active molecules into target cells47, including mRNAs, microRNAs, and proteins. In this study, we demonstrated that hucMSC-Ex could increase CK1δ and β-TRCP expression and promote YAP ubiquitination and degradation in ...