间充质干细胞(mesenchymal stem cell,MSC)源性外泌体(MSC derived exosome,MSC-Exo)是由MSC通过旁分泌作用产生的携带大量生物信息传播介质和活性物质的脂质双分子层包裹纳米级囊泡,可实现有选择性、定向性的细胞间信号转导,抑制炎症反应,促进受损组织的修复与再生。此文就MSC-Exo的生物学特性、作用机制及其在常见疾...
DC-derived exosome,DCex 外泌体miRNAs 环磷酰胺联合树突状细胞分泌的外泌体 MSCs-derived exosomes,MEX 人源肝细胞HepG2外泌体 胰腺β细胞外泌体 HPV阳性头颈部鳞状细胞外泌体 人脐带间充质干细胞来源的外泌体 小胶质细胞外泌体 人骨髓间充质干细胞(BM-MSC)来源的外泌体 大鼠骨髓间充质干细...
近年来,研究发现来源于 MSCs 的外泌体(MSCs-Exo)具有与 MSCs 相似的组织损伤修复和再生功能。 外泌体(exosome)是多种细胞分泌的膜外小囊泡,直径30 ~ 200nm,可以转运核酸、脂质和蛋白质,参与细胞间的信息交流。 与MSCs 相比,外泌体用于...
However, the MSC exosome's contents are not static, but rather a product of the MSC tissue origin, its activities and the immediate intercellular neighbors of the MSCs. As such, the exosome content produced by MSCs appears to be altered when MSCs are cultured with tumor cells or in the in...
[11,12]. In addition, MSC-derived exosomes (MSC-Exos) can recapitulate the biological potential of MSCs; therefore, they may substitute for cell therapy to achieve cell-free therapy [13,14]. The advantages of exosome utilization, when compared to their cellular counterparts, include a higher ...
SEM image demonstrated damage and collapse on both bacteria’s surfaces [82]. Another study revealed that bone marrow MSCs-derived exosome-loaded carboxyethyl chitosan-dialdehyde carboxymethyl cellulose hydrogel has heightened antibacterial impacts by notably hindering bacterial growth in comparison to ...
MSC-ex Mesenchymal stem cell-derived exosome. PBS Phosphate-buffered saline. ROS Reactive oxygen species. DCF, 2',7' Dichlorofluorescein. GPX4 Glutathione peroxidase 4. ferroptosis inhibitors NAC addition (Supplemental Fig. 1A–C). In addition, transmission electron microscopy images of mitochon- dr...
The efficacy of MSC-based therapies has been increasingly attributed to the paracrine secretion, particularly exosome. A growing number of studies found that exosome is a promising potential target for new therapies of PH [[9], [10], [11]], however, the molecular mechanisms are not fully ...
[2] Ti D, Hao H, Fu X, Han W. Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation. Sci China Life Sci 2016; 59:1305–12. [3] Li X, Liu L, Yang J, Yu Y, Chai J, Wang L, et al. Exosome derived from human umbilical cord mesenchymal stem cell media...
According to reported difference in the outcome of MSC therapies in GvHD patients,3 we assumed that the exosome preparations from different MSCs might differ in their immune-modulating activities. Hence, MSCs of four different unrelated bone marrow donors were raised initially. The MSC nature of exp...