Exosome-derived microRNAs in oral squamous cell carcinomas impact disease prognosismicroRNAExosomeOral squamous cell carcinomaPrognosisObjectives microRNA (miRNA) expression patterns have provided new insight as biomarkers of prognosis as well as novel therapeutic targets for several neoplasms. However, the ...
Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner. Cancer Lett 2009; 283: 168–175. Article CAS PubMed Google Scholar Nouraee N, Mowla SJ . miRNA therapeutics in cardiovascular diseases: promises and problems. Front Genet 2015; 6:...
ligands can boost tumor cell apoptosis [59], Natural killer, cell-derived exosomes with miR-186 exert cytotoxic effects on blastoma cells [60,61]. Neutrophils-derived exosomes, with the different constitutions of a vast repertoire of cytokines, immunosuppressive or stimulatory molecules, can be pro...
多项研究表明MSC-exosomes可抑制疤痕形成。通过高通量测序和功能分析证明,hucMSC-exosomes中携带的miRNA-125b和miRNA-145,在创面愈合过程中,可以通过抑制转化生长因子TGF-β/SMAD2通路来抑制成纤维细胞分化和过度聚集,进而减少过度纤维化和瘢痕形成[6]。 7、相关的临床研...
Exosome-derived miRNAsExo-miRNAsExtracellular vesiclesMicroRNAsOvarian CancerPrognostic and predictive roleTumor progressionExosome-derived miRNAs showed interesting ... D Fanale,LR Corsini,M Bono,... - 《Critical Reviews in Oncology》 被引量: 0发表: 2024年 Hypoxic BMSC-derived exosomal miR-210-3p pro...
近日,一篇名为“Exosome-derived tRNA fragments tRF-GluCTC-0005 promotes pancreatic cancer liver metastasis by activating hepatic stellate cells”的论文证实了外泌体衍生的tRNA片段tRF-GluCTC-0005通过激活肝星状细胞促进胰腺癌肝转移。 胰腺导管腺癌(PDAC)是一种极具致死性的实体瘤,其生存率低下,死亡率较高。
derived exosomes down-regulate the expressionBRG1via miR-21-5p and miR-155-5p, thus promoting the invasion and metastasis of colorectal cancer cells [63]. MiR-223 is a specific miRNA that affects a variety of immune cells, especially macrophages [64]. Yang et al. [65] found that miR-223...
对比评估了子宫内膜癌(EC)和疑似患者尿来源外泌体中miRNA的表达,表明不同的表达的miRNA可用作EC的生物标记物。 Tumor cells:肿瘤细胞来源的外泌体表面有特殊的抗原可以反映供体细胞性质,能够在癌细胞发生,转移和免疫调控中以及监控疾病发展和作为疾病诊断标志物起到重要作用。
cancers [52,65]. Exosomes derived from U251 human glioma cells include diverse proangiogenic elements which enhance endothelial cells (ECs) growth, immigration, and lumen construction [65]. Furthermore, GDEs control the angiogenic ability of EC by increased or decreased expression of miRNA. Xu et...