Likewise, paracrine factors could also mediate the main therapeutic effect of mesenchymal stem cells. Research has shown that mesenchymal stem cell-derived micro-exosomes, which may come from stem cells, accumulate in the ischemic tissue and regulate cell proliferation, apoptosis, inflammation, and ...
Exosomes secreted by cardiac progenitor cells (CPCs) under hypoxic conditions facilitate tube formation by endothelial cells, and exosome injection reduces the expression of profibrotic genes in TGF-β-stimulated fibroblasts. Exosomes derived from hypoxic CPCs improved cardiac function and reduced fibrosis a...
近日,研究人员在Stem cell research & therapy上发表研究成果,系统揭示了hESC-Exo和hiPSC-Exos的蛋白组份和miRNA组份构成,并与人脐带间充质干细胞来源外泌体进行比对,为3种干细胞外泌体临床前和临床实验提供重要参考。 研究发现,三种...
2022年3月3日,山东大学口腔医学院吴训伟研究员、郭泾教授团队在Stem Cell Research & Therapy上发表了题为“Exosomes derived from stem cells of human deciduous exfoliated teethinhibit angiogenesisin vivoandin vitrovia the transfer...
Wound healing is a complicated biological process that leads to the regeneration of damaged skin tissue. Determining the methods to promote wound healing has become a hot topic in medical cosmetology and tissue repair research. Mesenchymal stem cells (MSCs) are a group of stem cells with the pote...
MSC-derived exosomes are known to have positive effects on wound healing and scarring, regardless of their identity or [84]. When we compare cell-based therapy and exosome therapy, exosomes exert a much greater biological effect because they directly get fused to the damaged target cells, exosom...
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9:654–9. 21. Tadokoro H, Umezu T, Ohyashiki K, Hirano T, Ohyashiki JH. Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells. J...
Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review. Stem Cell Res Ther. 2022;13:192. https://doi.org/10.1186/s13287-022-02825-z. Article PubMed PubMed Central Google Scholar Cheng Y, Zeng Q, Han Q, Xia W. Effect of pH, ...
Intimal hyperplasia miRNA: MicroRNA MSCs: Mesenchymal stem cells PBS: Phosphate buffered saline SEM: Scanning electron microscopy TEM: Transmission electron microscopy References Dai C, Chu T, Li X, Jiang H, Liu T, Zhou Y et al. A novel UV-curable extravascular stent to prevent resten...
2022年9月5日中国科学院生物物理研究所姬广聚课题组在Stem cell research & therapy杂志上在线发表了题为“Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells”的研究论文(2022 Sep 5...