In MSCs, exosomal miR-223 contributes to cardioprotection during sepsis (25). However, miRs constitute a small fraction of the ncRNAs within exosomes (26). It is becoming increasingly clear that non-miR ncRNAs also underlie some forms of bioactivity (27). The emerging paradigm is as follows: ...
Kaplan–Meier analysis showed that the overall survival time of patients with PDAC expressing high levels of MALAT-1 was significantly lower than that of patients expressing low levels of MALAT-1. A multivariate analysis supported the notion that the MALAT-1 level is an independent prognostic ...
This adds a layer of complexity to the model discussed above, such that hypertrophy is followed by cell death and, finally, by the appearance of new adipocytes. This notion is supported by serial analysis of individual Zucker fatty rats, which appear to cycle between hypertrophy and hyperplasia ...
Fetal haematocrit may also be increased [77,110], however the impact of hypoxia on placental erythropoiesis is unknown. Placental erythropoietin (EPO) was increased in response to very acute severe hypoxia in mice [111] and qualitative analysis of the placenta has shown increased placental red ...
This miRNA is loaded into an argonaut protein to compose the RNA-induced silencing complex (RISC) [25]. The expression of the target mRNA is regulated by binding its 3′ end to the complementary 5′ end of the mature miRNA. Depending on the complementarity degree, mRNA can be repressed or...