今天给大家分享一篇2022年9月发表在Stem Cell Research & Therapy上的文章,题目为“Mesenchymal stem cell-derived exosome-educated macrophages alleviate systemic lupus erythematosus by promoting efferocytosis and recruitment of IL-17...
Apoptosis, a type of programmed cell death that plays a key role in both healthy and pathological conditions, releases extracellular vesicles such as apoptotic bodies and microvesicles, but exosome release due to apoptosis is not yet commonly accepted. Here, the reports demonstrating the presence of...
这篇文章于2023年2月发表于Nature Cell Biology（IF=28，Stiff matrix induces exosome secretion to promote tumour growth）,是一篇探讨肿瘤细胞微环境对肿瘤细胞外泌体分泌的影响及其机制的文章，做相关方向没有思路的同学可以借鉴一下。研究意义：组织纤维化和并发的胞外基质（Extracellular matrix，ECM）变硬与肝细...
Keywords exosome interleukin-8 PPARα glucolipid metabolism CD8+ T cell prostate cancer Research topic(s) CP: Cancer CP: Immunology Sorry, something went wrong. Please try again and make sure cookies are enabledCited by (11) Exosomes as a Therapeutic Strategy in Cancer: Potential Roles as Drug...
The present invention relates to mesenchymal stem cell-derived microparticles having activity that promotes the growth of corneal epithelial stem cells and/or corneal epithelial cells, activity that maintains corneal epithelial stem cells in an undifferentiated state or promotes the formation of colonies ...
Mesenchymal stem cell-derived exosomes in clinical trials Preclinical data have proven the safety of exosome therapy and scalability of their isolation methods from MSCs for clinical application. However, the use of MSC exosomes in clinical setting is limited due to the lack of established cell cultu...
exosome release, such as serum starvation, hypoxia and inflammation, change the surface and intracellular content of exosomes. Thus, to significantly advance exosome-mediated therapy in clinical trials, effective methods that maintain the homogeneity of MSC-derived exosomes, involve robust and standardized...
Exosome中含有细胞特异的蛋白、脂质和核酸,能作为信号分子传递给其他细胞从而改变其他细胞的功能。Exosome在体内存在的广泛性和获取的便捷性,已经成为了疾病诊断治疗的潜在有效方式,在精准医学发展上有着光明的前景。开展本次研讨会的目标是为了让刚接触...
Additionally, issues related to the standardization of exosome purification methods and the ethics of using human-derived cells still need to be addressed. Finally, further research is warranted to understand the dosage, route of administration, and potential impacts of exosomes on the human body in...
在一项新的研究中,来自美国加州大学圣地亚哥分校和中国医学科学院/北京协和医学院的研究人员鉴定出外泌体(exosome)是其中缺失的一环。相关研究结果于2017年9月21日在线发表在Cell期刊上,论文标题为“Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity”。