ExosomesExtracellular vesiclesMesenchymal stem cellsTumor angiogenesisAngiogenesis is a multistep process and various molecules are involved in regulating it. Extracellular vesicles are cell-derived particles, secreted from several types of cells and are known to mediate cell-to-cell communication. These ...
最新研究发现肿瘤细胞来源的外泌体(tumor cell-derived exosomes,TEXs)上修饰HMGN1功能域可增强DC的免疫原性,激活T细胞肿瘤杀伤能力,抑制小鼠肿瘤,相关研究结果发表在Nature Communications杂志上。 在该研究中,研究人员在TEXs上修饰N1ND(TEX-N1ND),用TEX-N1ND脉冲的DC(DCTEX-N1ND)在大量肿瘤负荷的同基因皮下肿瘤...
After release, exosomes can orchestrate on their parental cells, adjacent and distant cells in an autocrine, a juxtacrine and a paracrine manner. When they reached their target cells, the first way of uptake is to recognize receptors on the surface of the cell membrane and activate the correspon...
(DCs) activated by tumor cell lysates as antigens ex vivo, shows limited response rates in HCC patients. Here, we demonstrate that tumor cell-derived exosomes (TEXs), displaying an array of HCC antigens, can elicit a stronger immune response than cell lysates in vitro and in vivo. ...
Collectively, MALAT1 loaded by BC cell-derived Exo can accelerate BC cell metastasis and chemoresistance via disruption of miR-1-3p-mediated inhibition of the VASP/Rap1 signaling axis. 1. Introduction Breast cancer (BC) is not only the most prevalent cancer in women, but also accounts for ...
A large proportion of these exosome-related databases and online analysis applications can be used to analyze tumor models; however, few can be used to analyze tumor-associated immune cell-derived exosomes. Studies have increasingly reported not only that tumor cell-derived exosomes can act on the...
Here, we report that exosomes from bone marrow-derived cells (BMDCs) in tumor-bearing mice, but not in healthy mice, carry PD-L1. PD-L1 on these exosomes is biofunctional and can inhibit CD8T cell proliferation and activation in vitro and in vivo. The transfer of exogenous exosomes from ...
Notably, exosomes from HCC cells not only promoted HCC-specific cytolysis but also provided cross-protective effects against pancreatic cancer cells. Moreover, HCC-specific cytolysis, elicited by DCs pulsed with human HepG2 cell-derived exosomes, was observed across different human HCC cells ...
we describe an alternative mechanism of PD-L1 activity involving its secretion in tumor-derived exosomes. Removal of exosomal PD-L1 inhibits tumor growth, even in models resistant to anti-PD-L1 antibodies. Exosomal PD-L1 from the tumor suppresses T cell activation in the draining lymph node. Sy...
exosomes derived from the aforementioned four liver cancer cell types. Divided into two groups as before, the results were compared and shown as heatmaps in Fig.2a. Twenty-one of the most upregulated miRNAs (fold change > 10) in both two high-metastatic cancer cell-derived exosomes were ...