Tumor microenvironmentCholangiocarcinoma (CCA) refers to an aggressive malignancy with a high fatality rate and poor prognosis. Globally, the morbidity of CCA is increasing for the past few decades, which has progressed into a disease that gravely endangers human health. Exosomes belong to a class ...
Exosomes Derived from Colon Cancer Cells Promote Tumor Progression and Affect the Tumor Microenvironment Cancer-cell-derived exosomes confer oncogenic properties in their tumor microenvironment and to other cells; however, the exact mechanism underlying this p... M Kim,IT Son,Noh, Gyoung TaeWoo, So...
And the crosstalk among different cell types mediated by exosomes has proven to be strongly related to tumor progression and therapeutic response. For one perspective, cancer-cell-derived exosomes regulate the function of stromal cells in the microenvironment. For example, exosomes from HCC cells ...
Signal transduction pathway of exosomes in tumor microenvironment. The most important cells in tumor microenvironment mainly include CAFs, CSCs, MSCs, TMICs, etc. These four types of cells use exosomes to promote EMT, tumor metastasis and drug resistance through a variety of mechanisms. CAFs cancer...
in other words, nerves are already present within the microenvironment and the tumor acquires them by default. However, the clinical findings that some tumors of the same tissue are more innervated than others indicate instead an active, tumor-initiated process, similar to angiogenesis and lymphangiog...
8. Exosomes are small particles of endocytic origin with a size of 30–150 nm9. Secretion of exosomes by tumor cells significantly contributes to intercellular communication and subsequent reprogramming of the tumor microenvironment8. In addition to exosomal core proteins (such as CD9, CD63, ...
The miR in exosomes can also affect the tumor microenvironment. Communication between endothelial cells and tumor cells in the tumor microenvironment is required for cancer metastasis. Previous studies have confirmed that miR-29a expression is upregulated in colorectal cancer (CRC) tissues, and EMT-...
Emerging evidences show that exosomes derived from immunocytes, including dendritic cells, T cells, B cells, macrophages, natural killer cells and myeloid-derived suppressor cells, can play an intimate role in the crosstalk among immunocytes in a tumor microenvironment. In this review, we high...
Cancer-secreted exosomes influence tumor microenvironment and support cancer growth and metastasis. MiR-210 is frequently up-regulated in colorectal cancer tissues and correlates with metastatic disease. We investigated whether exosomes are actively released by HCT-8 colon cancer cells, the role of exosom...
Dendritic cells (DCs) are central for the initiation and regulation of innate and adaptive immunity in the tumor microenvironment. As such, many kinds of DC-targeted vaccines have been developed to improve cancer immunotherapy in numerous clinical trials