10. While such a mechanism likely contributes to tumor innervation, tumors release additional components that may also directly promote axonogenesis. Among these are extracellular vesicles such as exosomes. Exosomes are 30–150 nm vesicles that package...
Cancer exosomes induce tumor innervation. Nat. Commun. 9, 4284 (2018). Article PubMed PubMed Central Google Scholar Deborde, S. et al. Schwann cells induce cancer cell dispersion and invasion. J. Clin. Investig. 126, 1538–1554 (2016). Article PubMed PubMed Central Google Scholar ...
Cancer exosomes induce tumor innervation. Nat. Commun. 9, 4284 (2018). Article PubMed PubMed Central Google Scholar Tian, Z. et al. TIMP1 derived from pancreatic cancer cells stimulates Schwann cells and promotes the occurrence of perineural invasion. Cancer Lett. 546, 215863 (2022). ...
Cancer exosomes induce tumor innervation. Nat. Commun. 9, 4284 (2018). Article PubMed PubMed Central Google Scholar Furuhashi, S. et al. Ephrin receptor A4 expression enhances migration, invasion and neurotropism in pancreatic ductal adenocarcinoma cells. Anticancer Res. 41, 1733–1744 (2021)....
Cancer exosomes induce tumor innervation. Nat Commun. 2018;9. https://doi.org/10.1038/s41467-018-06640-0. Kosaka N, Iguchi H, Hagiwara K, Yoshioka Y, Takeshita F, Ochiya T. Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic micrornas regulate cancer cell ...
Tumor immunotherapy has transformed neoplastic disease management, yet low response rates and immune complications persist as major challenges. Extracellular vesicles including exosomes have emerged as therapeutic agents actively involved in a diverse range of pathological conditions. Mounting evidence suggests ...
Exosomes contain large amounts of RNAs, including miRNAs, mRNAs Exosomes mediated intercellular communication Considering that TDEs promote tumor survival and proliferation, induce matrix remodeling and neovascularization, and contribute to distant metastasis, exosome-mediated cell communication plays a crucial ...
until the conditions are favorable to generate cells genetically unstable and undifferentiated, with altered molecular signatures. At that stage, the cells might reach the brain microenvironment. Both the conditions, however, cause severe pain because of the involvement of tumor innervation. By contrast...
Cancer exosomes induce tumor innervation. Nat. Commun. 9, 4284 (2018). Article PubMed PubMed Central Google Scholar Furuhashi, S. et al. Ephrin receptor A4 expression enhances migration, invasion and neurotropism in pancreatic ductal adenocarcinoma cells. Anticancer Res. 41, 1733–1744 (2021)....
Cancer exosomes induce tumor innervation. Nat. Commun. 9, 1–15 (2018). Article CAS Google Scholar Mauffrey, P. et al. Progenitors from the central nervous system drive neurogenesis in cancer. Nature 569, 672–678 (2019). Article CAS PubMed Google Scholar Lu, R. et al. Neurons ...