检测miR-519d-3p对体内肿瘤生长的影响.结果:miR-519d-3p与TROAP存在靶向关系(P<0.05);在体外,miR-519d-3p过表达可抑制A549细胞增殖,迁移和侵袭,并促进细胞凋亡.此外,miR-519d-3p过表达可下调TROAP表达并降低β-Catenin,Axin2,C-myc蛋白水平(P<0.05);TROAP过表达对A549细胞的作用与之相反(P<0.05).同时,...
The cells pretreated with different concentrations of miR-519d-3p mimic (20, 40 or 80 nM) or antago-miR-519d-3p (10, 20 or 40 nM) or BAMBI vector or BAMBI siRNA as described previously were used for the CCK-8 assay. Cells (2×105well) were plated in a 96-well plate and prolife...
Knockdown of MMP-2 using a siRNA attenuated the increased trophoblast migration and invasion promoted by the miR-519d-3p inhibitor. In placentas from patients with PE or normal pregnancies, a negative correlation between the expression of MMP-2 and miR-519d-3p was observed using the Pearson ...
There are comments on PubPeer for publication: RETRACTED ARTICLE: MiR-519d-3p enhances the sensitivity of non-small-cell lung cancer to tyrosine kinase inhibitors (2021)
检测miR-519d-3p对体内肿瘤生长的影响.结果:miR-519d-3p与TROAP存在靶向关系(P<0.05);在体外,miR-519d-3p过表达可抑制A549细胞增殖,迁移和侵袭,并促进细胞凋亡.此外,miR-519d-3p过表达可下调TROAP表达并降低β-Catenin,Axin2,C-myc蛋白水平(P<0.05);TROAP过表达对A549细胞的作用与之相反(P<0.05).同时,...
胚胎植入失败是不孕不育的主要原因,尽管辅助生殖技术尤其体外受精-胚胎移植技术(invitrofertilizationandembryotransfer,IVF-ET)飞速发展,已成为治疗不孕不育的重要手段,然而反复种植失败仍然是该技术的瓶颈.高质量的胚胎,容受性的子宫内膜以及两者之间的有效对话是胚胎成功植入的重要因素;选择具有最佳种植潜能的胚胎进行移植...
Therefore, the present study assessed the expression level of miR-519d-3p in cervical cancer cells and examined the effects of miR-519d-3p overexpression on DDP resistance in cervical cancer cells. Moreover, the present study analyzed the potential regulatory mechanism of the miR-519d-3p/HIF-...
Overexpression of miR-519d-3p led to inhibited PCa cell proliferation, invasion and migration, and p53 overexpression was found to promote miR-519d-3p expression to suppress the malignant characteristics of PCa cells, while the additional E2F1 overexpression restored the malignant traits. Moreover, ...
Guangrao County People's Hospital, Dongying City, Shandong Province 257300, People's Republic of China Background: MiR-519d and miR-328-3p had tumor-regulatory properties in different cancers, but their combinatorial effects and potential common target in breast cancer had not been fully reported....
而抑制CyclinD1,MMP-2,MMP-9,MMP-14表达;抑制KPNA2表达后胶质瘤细胞增殖,迁移及侵袭能力均明显减弱,促进p21表达,而抑制CyclinD1,MMP-2,MMP-9表达;miR-519d-3p过表达同时上调KPNA2表达后部分逆转miR-519d-3p过表达对胶质瘤细胞增殖,迁移及侵袭的抑制作用.结论 miR-519d-3p可通过负向调控KPNA2表达而抑制...