对另一独立的 MB 患者队列进行的计算机分析表明,部分 miR-512-3p 靶基因也与预后特征相关。研究结果表明,miR-512-3p 可能与儿童 MB 的不良临床结局相关,提示其是一种潜在的预后生物标志物。<
We found six candidate target genes of miR-512-3p using DNA microarray data and target prediction software. Furthermore, we revealed that protein phosphatase 3, regulatory subunit B, alpha (PPP3R1), one of the six genes, was a miR-512-3p target using an in vitro experimental validation ...
miR-512-3p在乳腺癌中的表达及其功能研究
货号:ocu-miR-512b-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:ocu-miR-512b-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制...
Therefore, the anti-proliferative properties of Sorafenib were related to the down-regulation of miR-148b-3p and miR-512-3p. Caspase-3 activity was reduced by miR-122-5p and miR-505-5p, while it was increased by miR-222-5p (Figure 3C,D). Regarding the metastatic potential of miRNAs in...
【摘要】目的探究miR-101-3p在胃癌中的表达及其靶向STC-1基因调控PI3K/AKT信号通路对癌细胞侵袭转移、血管生成的作用机制。方法qRT-PCR检测胃癌组织及BGC-823细胞中miR-101-3p和STC-1 mRNA的表达,并分析miR-101-3p表达与患者临床病理...
miR-512-3PDUSP1自噬凋亡目的探究白藜芦醇(resveratrol,RES)抑制葡萄膜黑色素瘤细胞(choroidal melanoma cells,MUM2B)自噬并促进其凋亡的调控作用及机制.方法将MUM2B分为对照组,实验组,分别用不同浓度的RES(0,10,20,40,60,80μmol·L-1)处理细胞.划痕实验检测细胞迁移率,CCK-8检测细胞活力,流式细胞术...
Mechanistically, Keleh-like ECH-associated protein 1 (Keap1) was proved to be a functional target of miR-512-3p. Furthermore, silencing Keap1 limited ox-LDL-mediated EC cell dysfunction, while over-expressing Keap1 mitigated the exosomal miR-512-3p-mediated protective effect in Ox-LDL-induced...
(P<0.05);qPCR结果显示,TSCC患者唾液外泌体中miR-512-3p水平较健康对照者明显升高(P <0.001),并且miR-512-3p过表达组的外泌体可明显促进细胞增殖(P <0.05),其细胞p53表达水平降低(P<0.001).荧光素酶报告基因检测结果显示,GAS2为miR-512-3p靶基因.结论 TSCC患者唾液外泌体可通过miR-512-3p促进癌细胞增殖,...
Our results have shown that miR-512-3p could be associated with poor clinical outcomes in pediatric MB, suggesting that miR-512-3p is a potential biomarker of prognosis.doi:10.1007/s12311-025-01812-3Carolina Alves Pereira CorreaPablo Shimaoka Chagas...