MiR-489-3p re-expression or BDNF knockdown inhibited GBM cell proliferation, migration, and invasion, and promoted apoptosis. BDNF was a target of miR-489-3p, and BDNF up-regulation reversed the effects of miR-489-3p on GBM cells. The protein levels of p-AKT and p-PI3K were notably ...
摘要 本发明公开了一种miR‑489‑3p在制备诊断和治疗人骨质疏松症药物中的应用。技术方案是检测老龄骨质疏松症患者股骨组织样本,发现miR‑489‑3p在人骨质疏松骨组织样本中低表达,可作为诊断骨质疏松症的标志基因。通过设计制备miR‑489‑3p的模拟物及拮抗剂,转染到小鼠前成骨细胞MC3T3‑E1中,进行矿化...
1.miR-489-3p作为Brachyury阳性肿瘤的分子标记物的应用。 2.miR-489-3p在制备早期筛查或诊断Brachyury阳性肿瘤试剂或试剂盒中的 应用。 3.根据权利要求2所述的miR-489-3p在制备早期筛查或诊断Brachyury阳性 肿瘤试剂或试剂盒中的应用,其特征在于,所述的Brachyury阳性肿瘤是指该 肿瘤中Brachyury呈现出高水平的表达。
LncRNALINC01446promotesglioblastomaprogressionbymodulating miR-489-3p/TPT1axis LiZhang a,1 ,QinWang b,1 ,FeiWang c ,XiangZhang a ,LiZhang d ,YingTang e , ShaoyunWang f,* a ExperimentCenterofBasicMedicalSciencesofKunmingMedicalUniversity,Kunming,650500,China b GeriatricsHospitalofYunnan,Kunming,650...
目的miRNA通过调节相应靶基因和各种信号通路的表达,参与肺癌的产生与扩散,miR-489-3p可作为靶向治疗靶点,并且已被证实在多种肿瘤中起抑癌作用,微小染色体维持蛋白(MCM)异常表达与肿瘤细胞增殖,侵袭,转移密切相关.本文miR-489-3p通过调控MCM2影响肺癌细胞的增殖.方 法本课题将以从中国科学院上海细胞库购买了肺癌细胞...
本发明涉及医学生物检测技术领域,本发明应用microRNA芯片技术筛选出被Brachyury调控后发生显著上调的若干microRNAs,并对这一系列microRNAs进行了RealTime PCR验证.本发明提供了Brachyury阳性肿瘤的分子标记物,该分子标记物miR4893p在肺癌患者中呈现显著高表达,而在其它肺部实质性病变患者和正常人群中则未见表达水平异常.本发明...
miR-489-3p和PTEN mRNA的表达.根据miR-489-3p的相对表达量均值将BC患者分为低表达组(≤0.36)70例和高表达组(>0.36)40例,并分析miR-489-3p表达在BC患者不同临床病理特征中的变化.双荧光素酶实验验证miR-489-3p和PTEN的靶向关系.选择miR-489-3p表达最低的T24细胞进行转染实验,T24细胞随机分组为对照组,miR-...
Upregulation of miR-489-3p and miR-630 inhibits oxaliplatin uptake in renal cell carcinoma by targeting OCT2 OCT2mi RNARenal cell carcinomaEpigenetic regulationOxaliplatinRenal cell carcinoma(RCC) is one of the most common malignant tumors affecting the urogenital system, accounting for 90% of ...
miR-489-3p/SIX1 Axis Regulates Melanoma Proliferation and Glycolytic Potentialdoi:10.1016/j.omto.2019.11.001Xuhui YangXiang ZhuZhifeng YanChenxi LiHui ZhaoLuyuan MaDeyu ZhangJuan LiuZihao LiuNan DuElsevier
MiR-489-3p reduced pancreatic cancer proliferation and metastasis by targeting PKM2 and LDHA involving glycolysisdoi:10.21203/RS.3.RS-58138/V1Dan Zhangzhiwei HeYiyi ShenJie wangTao LiuJianxin JiangFrontiers Media SA