1.mir-495-3p在制备治疗脊髓损伤的药物中的应用。 2.mir-495-3p在制备抑制脊髓损伤后神经元细胞凋亡的药物中的应用。 3.mir-495-3p在制备b细胞淋巴瘤-2相关x蛋白调节剂中的应用,其特征在于,所述mir-495-3p下调b细胞淋巴瘤相关x蛋白的表达水平。 4.如权利要求1-3任一项所述的应用,其特征在于,所述mir-495...
生信分析子宫内膜癌组织较正常癌旁组织has-miR-495-3p表达明显降低;高表达has-miR-495-3p子宫内膜癌患者组明显较低表达组患者生存时间长;相关性分析结果表明BUB1与miR-495-3p表达水平呈负相关。 2.4 miR-495-3p靶向BUB1 mRNA的3'非编码区 双荧光素酶报告实验表明,SNGM细胞中与miRNA NC组相比,过表达miR-495-3...
si-NEAT1组T淋巴细胞凋亡率显著降低(P<0.05),Bcl-2蛋白水平显著升高(P<0.05),Bax蛋白水平显著降低(P<0.05),miR-495-3p的表达水平显著升高(P<0.05).结论重症肺部感染患者血清中NEAT1的表达水平升高,miR-495-3p的表达水平降低,二者对重症肺部感染具有一定诊断价值,沉默NEAT1可能通过上调miR-495-3p表达从而抑制...
IL-6R是miR-495-3p的靶基因，miR-495-3p负调控IL-6R表达。结论：miR-495-3p 通过靶向IL-6R抑制宫颈癌细胞的增殖和转移，提示miR-495-3p在宫颈癌中具有抑癌作用。［关键词］miR-495-3p；白细胞介素6受体基因；宫颈癌；细胞增殖；转移 miR-495-3p inhibits proliferation and metastasis of cervical cancer ...
在机制上,circEZH2可能作为ceRNA调节miR-495-3p,促进TPD52表达,同时激活NF-κB通路促进MRC-5活化。 结论非小细胞肺癌细胞来源外泌体circEZH2可能通过miR-495-3p/TPD52轴激活NF-κB通路促进成纤维细胞活化。 关键词: 肺肿瘤;非小细胞肺癌;circEZH2;外泌体;成纤维细胞;核因子κB ABSTRACT ObjectiveTo study the ...
Among them, available studies proposed that miR-495–3p is a pivotal player in cancer pathogenesis. These studies showed that the expression level of miR-495–3p decreased in various cancer cells, suggesting its tumor suppressor role in cancer pathogenesis. Long noncoding RNAs (lncRNAs) and ...
摘要 目的探讨血清miR-183-3p、miR-495-3p表达与食管癌患者临床病理特征及预后的关系。方法选择2017年12月—2020年12月解放军总医院第三医学中心胸外科诊治食管癌患者105例作为食管癌组,随访3年根据患者...展开更多 Objective To explore the relationship between serum miR-183-3p and miR-495-3p expression and...
However, miR-mediated regulation of Sphk1 in Non-small cell lung cancer (NSCLC), continues to be elusive. miR-495 is highly downregulated and worsens NSCLC prognosis. The present study demonstrates Sphk1 upregulation and poor prognosis in NSCLC. However, miR-495–3p directly targets Sphk1, ...
Purpose: To demonstrate whether miR-495-3p promote the occurrence of colon cancer and development of colon cancer stem cells by inhibiting Wnt inhibitory factor (WIF1).Methods: The level of MiRNA and mRNA in cells were tested by real-time polymerase chain reaction (RT-PCR). Cell viability was...
货号:oar-miR-495-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:oar-miR-495-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...