在Ⅰ～Ⅱ期PHC患者血清中miR-142-3p、miR-493-5p表达水平显著低于Ⅲ期和Ⅳ期,分期越高其表达水平越低,进一步证实了血清miR-142-3p、miR-493-5p水平变化与PHC患者病情密切相关。通过ROC曲线分析发现,血清miR-142-3p和miR-493-...
结论miR-493-5p可抑制卵巢癌SKOV3细胞的增殖、迁移和侵袭，其机制可能与靶向调控GIT1以及MEK1/2-ERK1/2通路有关,并可为卵巢癌的诊断、预防和治疗提供新靶点。关键词：miR-493-5p；GIT1；MEK1/2-ERK1/2通路；卵巢癌;侵袭 中图分类号:R737.31文献标志码:A miR-493-5p inhibits the proliferation and ...
MiR-493-5p targeted and inhibited TAB2 expression in LPS-induced ATDC5 cells (p < 0.001). TAB2 overexpression reversed the suppression of TAB2 by miR-493-5p in LPS-induced ATDC5 cell injury (p < 0.001). Conclusion: MiR-493-5p alleviates LPS-induced inflammation of ATDC5 ...
To determine whether FUT4 expression is indeed regulated by miR-493-5pin vitro, the MDA-MB-231 cells were transfected with miR-493-5p agomir, while the MCF-7 cells were transfected with the miR-493-5p antagomir. As expected, miR-493-5p agomir-treated cells showed higher expression of miR...
货号:oar-miR-493-5p 原价:￥4030 现价:￥3098.38节省:￥932 规格:1 kits 说明:oar-miR-493-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录产...
Purpose: To investigate the effect of miR-493-5p in lipopolysaccharide (LPS) -induced ATDC5 chondrogenic cells. Methods: The MTT assay was used to determine the viability of LPS-induced ATDC5 cells. ENCORI (starbase.sysu.edu.cn/) was used to predict the target of miR-493-5p. Quantitative...
miR-493-5p suppresses hepatocellular carcinoma cell proliferation through targeting GP73 Biomedicine & Pharmacotherapy Volume 90,June 2017, Pages 744-751 Purchase options CorporateFor R&D professionals working in corporate organizations. Academic and personalFor academic or personal use only. ...
We found that miR-493-5p mediated part of its tumor-suppressor activity by abrogating overexpression of insulin-like growth factor 2 () and the-derived intronic oncomir miR-483-3p in HCC cells characterized byloss of imprinting (LOI). In summary, this study describes an unknown miRNA-...
Taken together, our data suggest that FUT4 may have a potential role in the treatment of breast cancer, as well as miR-493-5p is a novel regulator of invasiveness and tumorigenicity of breast cancer cells through targeting FUT4. The miR-493-5p/FUT4 pathway has therapeutic potential in ...
目的探讨长链基因间非编码RNA-重编程调节因子(Linc-ROR)及微小RNA181a-5p(miR-181a-5p)在卵巢高级别浆液性癌(HGSOC)组织中的表达,并探讨两者对卵巢上皮性癌(卵巢癌)细胞恶性生物学行为的影响及作用机制。 方法(1)收集2019年6月...