在不受血脑屏障(blood-brain barrier, BBB)限制的情况下靶向递送miR-486-3p,是一种缓解SAH相关神经炎症的有前景的策略。 本研究通过修饰外泌体(Exo)构建RVG-miR-486-3p-Exo(Exo/miR),实现miR-486-3p至脑部的靶向递送。通过神...
miR-486-3p增殖迁移银屑病是一种容易反复发作的慢性炎症性皮肤病,其发病机制尚不明确.目前认为它是一种由环境因素和遗传因素共同导致的以固有免疫和适应性免疫功能紊乱所致的疾病.其中Th1和Th17细胞及其分泌的多种细胞因子参与了疾病的发生. 银屑病的病理改变是由于角质形成细胞(KC)的增殖过快,分化受阻所致,而异常...
目的采用生物信息学方法分析miR-486-3p靶基因在甲状腺乳头状癌(PTC)中的差异表达情况及临床意义。方法根据肿瘤基因图谱中PTC肿瘤样本及配对样本的表达数据筛选miR-486-3p差异表达基因,使用ClusterProfilerR包对差异表达基因进行GO和KEGG注释,ggplot2R包绘制GO二级分类柱形图及KEGG注释统计图,将预测miR-486-3p靶基因并与...
中的应用,本发明提供miR‑486‑3p相关生物材料的制备如下(a1)或(a2)产品中的应用:(a1)制备治疗蛛网膜下腔出血症的产品;(a2)制备抑制蛛网膜下腔出血导致的神经炎症的产品;所述miR‑486‑3p的相关生物材料为miR‑486‑3p,或者装载有miR‑486‑3p的外泌体,或者能够促进所述miR‑486‑3p表达的...
BioTNT cgr-miR-486-3p qPCR试剂盒 产品中心 >> 试剂 >> 分子生物学试剂 >> microRNA qPCR Kits关 闭 分类:microRNA qPCR Kits 品牌:BioTNT 货号:cgr-miR-486-3p 原价:￥4030 现价:￥3098.38节省:￥932 规格:1 kits 说明:cgr-miR-486-3p 特异性茎环引物试剂盒 ￥615 ...
To shed some light on the molecular mechanisms through which miR-486-3p affects HPCs lineage commitment, we profiled the gene expression changes upon miR-486-3p overexpression in CD34+ cells. Among the genes downregulated in miR-486-3p-overexpressing HPCs and computationally predicted to be miR...
miR-486-3p, XRCC1, CYP1A1, and related genes in the cancer cells and tissues were detected by RT-qPCR, Western blot, or immunohistochemistry. The current study found that miR-486-3p was low-expressed in lung cancer. MiR-486-3p, which has been found to target XRCC1 and CYP1A1, was...
miR-486-3p高表达病人生存率显著高于低表达病人,预示miR-486-3p在癌症中发挥着重要作用.因此,本研究将开展miR-486-3p在癌症中的作用以及机制分析.随着miRNA存贮平台的建立以及生物信息学的发展,miRNA互补对特殊结构被发现,而本研究的miR-486刚好能够被加工成互补miRNA对,即miR-486-5p与miR-486-3p成熟体互补配对,...
(0.86±0.06 vs 0.51±0.05,P<0.001)和克隆形成数(89.62±7.35 vs 45.81±4.48,P<0.001).circ_0001361与miR-486-3p直接结合.下调miR-486-3p表达显著性减弱干扰circ_0001361对MDA-MB-231细胞克隆形成数,凋亡率和细胞光密度值的影响(P<0.001).[结论]干扰circ_0001361通过促进miR-486-3p表达来诱导乳腺癌细胞凋亡...
There are comments on PubPeer for publication: Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1 (2022)