结果发现,过表达miR-429-3p可上调APP蛋白水平,但不影响BACE1蛋白水平;而使用A-miR-429抑制miR-429-3p则下调了APP、BACE1和PS1的蛋白水平,但A-miR-429不能改变Mkp-1-/-细胞中APP、BACE1和PS1的蛋白水平。 为了进一步阐明miR-429-3p在体内AD发病机制中的作用,研究人员通过鼻内给药将CY3标记的A-miR-429递送到...
aca-miR-429-3p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:aca-miR-429-3p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:aca-miR-429-3p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方...
miR-429-3pExosomesRac1PAHInflammationRecent studies have emphasized the critical role of Telocytes (TCs)-derived exosomes in organ tissue injury and repair. Our previous research showed a significant increase in ITGB1 within TCs. Pulmonary Arterial Hypertension (PAH) is marked by a loss of ...
动脉粥样硬化患者血清中miR-135b-5p和miR-499a-3p的表达水平分别提高了8.77倍和1.78倍.3,miR-135b-5p和miR-499a-3p抑制共同下游靶基因MEF2C的表达:与对照组相比,升高miR-135b-5p和miR-499a-3p水平后,MEF2C的蛋白水平分别下降了33.41%和20.48%,Luciferase实验荧光强度分别下降了45.67%和26.39%,而不影响MEF2C...
近日,兰州大学第二医院王志平教授团队郜栋阳和马俊海博士分别在《Journal of Oncology》和《Int J Clin Exp Med》上报道了 Y-box 结合蛋白 1 (YB-1) 与膀胱癌的预后密切相关,且通过 miR-29b-3p-VEGFA 通路促进膀胱癌的血管...
MiR-409-3p and MiR-1896 co-operatively participate in IL-17-induced inflammatory cytokine production in astrocytes and pathogenesis of EAE mice via ... X Liu,F Zhou,Y Yang,... - 《Glia》 被引量: 0发表: 2019年 MiR-409-3p and MiR-1896 co-operatively participate in IL-17-induced inflam...
近日,来自上海交通大学医学院仁济医院胃肠外科赵刚、赵恩昊、郁丰荣课题团队的研究人员发现,缺氧HIF-1α诱导的miR-301a-3p表达以及缺氧胃癌细胞分泌的外泌体miR-301a-3p可促进肿瘤上皮间质转化和胃癌进展。该研究发表于Oncogene杂志上。...
Our study suggests that Dex alleviates CICI by modulating miR-429-3p expression in rats. Thus, Dex may be effective in preventing the side effects of cisplatin.doi:10.1007/s13205-020-02217-1Chang LiDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China...
Therefore, we conclude that miR-378a-3p regulates skeletal muscle growth and promotes the differentiation of myoblasts through the post-transcriptional down-regulation of HDAC4. 展开 关键词: Cell apoptosis cell proliferation HDAC4 miR-378a-3p muscle differentiation ...
Similar to SOAT1 mRNA accumulation, the gga-miR-181a-5p expression was gradually elevated during development, but the concentration of gga-miR-429-3p was in the opposite direction. Transfection with gga-miR-181a-5p or gga-miR-429-3p inhibited TGFBR1 and SOAT1 in EECs. The 3' untranslated...