本发明涉及miR35915p作为先天性心脏病合并肺动脉高压诊断标志的应用;还涉及一种用于检测先天性心脏病合并肺动脉高压的检测试剂盒,包括用于检测miR35915p表达量的检测试剂,通过使用本发明提出的血浆中的miR35915p表达量作为分子标志,可对先天性心脏病和肺动脉高压进行高精度的动态监控,并进一步证明miR35915p可以成为先天...
The correlation between the miR-3591-5p expression and various clinical indices, as well as its diagnostic value for CHD-PAH patients, were analyzed.The plasma levels of miR-3591-5p were significantly higher in the patients in the no PAH group, mild PAH group, and moderate to severe PAH ...
Ectopic expression of USP33 or PPM1A partially abolished the effects of miR-3591-5p on EMT and TGF-尾/Smad2/3 activation. Conclusion: The present study revealed the critical role of miR-3591-5p/USP33/PPM1A in radiation-induced EMT via TGF-尾 signaling and may suggest novel ...