本发明涉及miR35915p作为先天性心脏病合并肺动脉高压诊断标志的应用;还涉及一种用于检测先天性心脏病合并肺动脉高压的检测试剂盒,包括用于检测miR35915p表达量的检测试剂,通过使用本发明提出的血浆中的miR35915p表达量作为分子标志,可对先天性心脏病和肺动脉高压进行高精度的动态监控,并进一步证明miR35915p可以成为先天性...
③ SAKI 组患者血清 VE-cadherin 水平明显高于对照组(mg/L :22.39±5.24 比 15.54±4.78,P<0.05).④ 相关性分析显示,miR-125b-5p 表达水平与血清中 VE-cadherin 水平呈正相关 (r 值为 0.743,P 值为 0.001).结论 SAKI 患者血清 miR-125b-5p 表达水平与血清中的 VE-cadherin 水平 呈正相关,两者间可能...
Tumor-derived exosomes deliver the tumor suppressor miR-3591-3p to induce M2 macrophage polarization and promote glioma progression Article Open access 09 September 2022 Exosomal miR-155-5p derived from glioma stem-like cells promotes mesenchymal transition via targeting ACOT12 Article Open access ...
Tumor-derived exosomes deliver the tumor suppressor miR-3591-3p to induce M2 macrophage polarization and promote glioma progression Article Open access 09 September 2022 The dual role of glioma exosomal microRNAs: glioma eliminates tumor suppressor miR-1298-5p via exosomes to promote immunosuppressive...
Specificity was confirmed for six microRNAs (hsa-miR-1271-5p, hsa-miR-22-3p, hsa-miR-3591-3p, hsa-miR-377-3p, hsa-miR-4717-5p, hsa-miR-96-5p) by disrupting their seed sequence at the 3′ untranslated region of RGS2. Hsa-miR-4717-5p showed the most robust effect on RGS2 and ...
(miR-4732-3p, miR-486-5p, and miR-139-3p) stood out (Fig.1A). Considering that miR-486-5p and miR-139-3p have been extensively studied in various malignancies [14,15], but the role of miR-4732-3p remains largely unknown, we therefore explored the expression patterns of miR-4732-3p...
Drug Design, Development and Therapy Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH Exosomes Derived from Hypoxic Glioma Cells Reduce the Sensitivity of Glioma Cells to Temozolomide Through Carrying miR-106a-5p Peizhang Wu1,2, Jun Guo2, ...
Drug Design, Development and Therapy Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH Exosomes Derived from Hypoxic Glioma Cells Reduce the Sensitivity of Glioma Cells to Temozolomide Through Carrying miR-106a-5p Peizhang Wu1,2, Jun Guo2, ...
In oral squamous cell carcinoma, SOCS2 is downregulated and inversely correlated with the level of miR-424-5p. There exists a signal-amplifying loop in which IL-8 drives activity of STAT5, STAT5 induces the expression of miR-424-5p, and miR-424-5p enhances the activity of STAT5 by ...
Ectopic expression of USP33 or PPM1A partially abolished the effects of miR-3591-5p on EMT and TGF-尾/Smad2/3 activation. Conclusion: The present study revealed the critical role of miR-3591-5p/USP33/PPM1A in radiation-induced EMT via TGF-尾 signaling and may suggest novel ...