Dual‐LUC assay confirmed that miR‐3064‐5p could target and inhibit SIRT6. Knockdown of SIRT6 inhibited inflammatory cytokine (IL‐6, IL‐1β, IFN‐γ, and TGF‐β1) levels and apoptosis. The results of the co‐IP assay showed that SIRT6 interacted with PCSK9, and knockd...
Dual-LUC assay confirmed that miR-3064-5p could target and inhibit SIRT6. Knockdown of SIRT6 inhibited inflammatory cytokine (IL-6, IL-1尾, IFN-纬, and TGF-尾1) levels and apoptosis. The results of the co-IP assay showed that SIRT6 interacted with PCSK9, and knockdown of SIRT6 ...
背景 动脉粥样硬化是2型糖尿病(T2D)患者的主要并发症和死因.脂质代谢紊乱和炎症是动脉粥样硬化发生发展的重要病理因素,已有研究表明miR-21,miR-122,miR-33a和miR-3064-5p不同程度参与调控脂质代谢和炎症,提示它们可能参与调控动脉粥样硬化的发生和发展.目前已有一些研究报道了miRNAs在T2D或动脉粥样硬化中的调控作用,但...
miR-3064–5pHuman mesenchymal stem cells (hMSCs) are multipotent cells that can be differentiated into different cell types including osteoblasts. Herein we aimed to assess the regulation of transcription factor mesenchyme homeobox 1 (Meox1) in the osteogenic differentiation of hMSCs and to determine ...