Dual‐LUC assay confirmed that miR‐3064‐5p could target and inhibit SIRT6. Knockdown of SIRT6 inhibited inflammatory cytokine (IL‐6, IL‐1β, IFN‐γ, and TGF‐β1) levels and apoptosis. The results of the co‐IP assay showed that SIRT6 interacted with PCSK9, and knockd...
We measured the expression levels of identified miRNAs (miR-340-5p, miR-6504-5p, miR-3064-3p, and miR-377-3p) by using TCGA miRNA datasets. Surprisingly, among these miRNAs, only miR-340-5p exhibited downregulated expression in LUAD tissue samples (Fig. 3a, Supplementary Fig. 4D-F). ...
These findings indicated that miR-4745-5p and miR-6798-5p are serum/glucose starvation-driven miRNAs for hnRNP A1 and validated the λN/boxB system as a simple and useful method for detecting mRNA 3ʹUTR-bound miRNA.Keywords microRNA hnRNP A1 λN/boxB system serum/glucose starvation ...
基于PTC 患者的 miRNA 表达水平,通过Cox回归分析和log-rank检验,发现五种特征性 miRNA(hsa-miR-206、hsa-miR-299-3p、hsa-miR-299-5p、hsa-miR-496 和 hsa-miR-509-3-5p)与总生存期显著相关 (p<0.05) (图2a)。进一步分析...
5p inhibitor | hsa-miR-12121 inhibitor | mmu-miR-6384 mimic | mmu-miR-7081-5p inhibitor | hsa-miR-9902 antagomir | mmu-miR-3080-3p inhibitor | mmu-miR-12182-5p antagomir | hsa-miR-6821-3p mimic | mmu-miR-7119-5p agomir | mmu-miR-6980-3p agomir | hsa-miR-511-3p antagomir |...
Nine microRNAs (miR-28-5p, miR-129-5p, miR-136-5p, miR-410-3p, miR-424-5p, miR-485-5p, miR-665, miR-708-5p, and miR-3064-5p) were predicted to interact with LINC00665 and BCL9L both (Supplementary Table 6). To verify their interaction with LINC00065, we overexpressed LINC00665...
2型糖尿病ApoE-/-小鼠miR--21,miR--122,miR--33a和miR--3064-5p表达及其与动脉粥样硬化进展的相关性研究 背景 动脉粥样硬化是2型糖尿病(T2D)患者的主要并发症和死因.脂质代谢紊乱和炎症是动脉粥样硬化发生发展的重要病理因素,已有研究表明miR-21,miR-122,miR-33a和miR-306... 汤嘉琪 - 南方医科大学 被引量...
对miR-21-5p相对表达量的影响:与6月龄正常组比较,假手术组大鼠股骨组织miR-21-5p相对表达量无明显变化;与假手术组比较,模型组大鼠股骨组织miR-21-5p相对表达量明显升高(P<0.05);与模型组比较,雌激素组,阿仑膦酸钠组,菟丝子提取物组,菟丝子醇提物低,中,高剂量组大鼠股骨组织miR-21-5p相对表达量均降低,其中...
产品活性:hsa-miR-3059-5p mimic 是一种化学合成的miRNA模拟物,能模拟内源性miRNA,上调miRNA活性,用于功能获得性(gain-of-function)研究。 研究领域:Epigenetics 作用靶点:MicroRNA 相关产品:hsa-miR-4728-3p agomir | hsa-miR-126-3p agomir | rno-miR-6323 antagomir | mmu-miR-6395 inhibitor | hsa-miR...