Here, we demonstrated miR-351-5p as a causative factor in hippocampal neural progenitor cell death through modulation of the mitochondrial GTPase, Miro2. Downregulation of Miro2 by siMiro2 induced cell death, similar to miR-351-5p, whereas ectopic Miro2 expression using an adenovirus abolished ...
miR-351-5p expression increased whereas the level of Miro2 decreased in the hippocampus of AD model mice, emulating expression in AD patients. Collectively, the data indicate the mitochondrial fission and accompanying mitophagy by miR-351-5p/Miro2 axis as critical in...
Part C 为指标的特异性引物试剂盒,试剂盒包括进行qPCR的上下游引物,以及逆转录使用的特异性茎环引物,该部分可以单独购买; 另试剂盒中提供一支RNA 酶DNA 酶free的双蒸水,可用于360次体系的配制。 本试剂盒目前订购,还可赠送内参的特异性引物试剂盒,该试剂盒包括检测该内参的qPCR上下游引物,以及逆转录使用的特异性...
目的探究褪黑素能否通过circPtpn14/miR-351-5p/5-LOX信号通路减轻铁死亡,从而保护血脑屏障. 方法将30只C57BL/6雄性小鼠随机分为假手术组,TBI组以及TBI+褪黑素治疗组,并通过CCI装置建立TBI模型,随后采用RNA-Seq技术筛选差异表达的circRNA.采用PCR和FISH对circPtpn14(mmu_circ_0000130)的性质进行鉴定.采用生物信息学...
miR-371-5p down-regulates pre mRNA processing factor 4 homolog B (PRPF4B) and facilitates the G1/S transition in human hepatocellular carcinoma (vol 335, pg 351, 2013) 来自 国家科技图书文献中心 喜欢 0 阅读量: 176 作者:RY Liu,CF Diao,Y Zhang,N Wu,HY Wan,XY Nong,M Liu,H Tang ...
本研究旨在探索TN模型中TG上Kv1.1和miR-21-5p的关系,评估miR-21-5p是否对Kv1.1有调控作用,为TN的治疗提供新的靶点。方法:将48只SD大鼠随机分为6组:1)假手术组(sham组,n=12),大鼠仅在术侧切口缝合,不结扎神经;2)Sham+agomir NC组(n=6),sham大鼠通过脑立体定位注射方法于术侧TG微量注射agomir NC;3)Sham...
CircFoxo3调节miR-130a-5p
The expression of molecules in the four potential ceRNA regulatory networks was detected by qRT-PCR in bronchial and lung tissues, and the results suggested that the expression of this regulatory network, chr9:52042693|52047844-miR-351-5p-Pten, was consist...
Relative miRNA expression levels of miR-20b-5p, -212, -351 and miR-let-7f in the rat cortex following 5 or 10 days of hypoxia.Yilin, Yang
Furthermore, miR-351-5p mimic and inhibitor experiments in IEC-6 cells further proved that dioscin up-regulated MAPK13 expression by decreasing miR-351-5p level to inhibit inflammation and apoptosis. Therefore, dioscin showed protective effect against II/R injury via adjusting miR-351-5/MAPK13-...