miR-361-5p 1.研究背景和意义: 宫颈癌是女性生殖系统中最常见的恶性肿瘤之一。尽管宫颈癌的发病机制尚不完全清楚,但具有重要作用的某些转录因子和信号通路已被鉴定。其中,上皮间充质转化(epithelial-mesenchymal transition,EMT)被认为在宫颈癌的进展过程中发挥着重要的作用。近年来,miRNA的表达异常与肿瘤的发生、发展...
Mechanistically, we found that miR-361-5p inhibited the proliferation of BC cells by suppressing glycolysis. FGFR1, a promoter of glycolysis-related enzyme, was identified as the target of miR-361-5p that promoted glycolysis and repressed oxidative phosphorylation. Furthermore, we demonstrated that ...
Results: miR-196-5p and miR-361-5p were, respectively, up- and down-regulated in COPD patients compared with healthy controls. Luciferase assays demonstrated that miR-361-5p and miR-196-5p were, respectively, targeting abca1 and arhgef12 3ʹUTR in BEAS-2B cells. GS significantly ...
摘要 目的探讨胃癌组织微小核糖核酸(miR)-23a-3p、miR-361-5p表达与磷脂酰肌醇3激酶(PI3K)/蛋白激酶B(AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路和预后的关系。方法采用实时荧光定量聚合酶链反应...展开更多 Objective To investigate the relationship between the expression of microRNA(miR)-23a-3p and miR-...
差异性表达(7种上调,2种下调),其中miR⁃361⁃5p 的表达显著上调㊂结论 番石榴叶提取物干预后影响了大鼠胰腺中microRNA 的表达,并可能通过调控miR⁃361⁃5p 的表达调节胰岛β细胞去分化,从而降低血糖㊂【关键词】 2型糖尿病; 番石榴叶; Zucker 糖尿病肥胖大鼠; 胰腺; miR⁃361⁃5p ...
Results: miR-196-5p and miR-361-5p were, respectively, up- and down-regulated in COPD patients compared with healthy controls. Luciferase assays demonstrated that miR-361-5p and miR-196-5p were, respectively, targeting abca1 and arhgef12 3ʹUTR in BEAS-2B cells. GS significantly ...
MiR-361-5p/abca1 and MiR-196-5p/arhgef12 Axis Involved in γ-Sitosterol Inducing Dual Anti-Proliferative Effects on Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease Hui-fen Shen, Ying Liu, Ping-ping Qu, Yu Tang, Bing-bing Li & Guo-liang Cheng Pages 2741-2753 | ...
Nell1/EVs的骨诱导能力主要在于显著下调了miR-25-5p。MiR-25-5p 可通过靶向Smad2并抑制SMAD和ERK信号通路的激活来抑制骨生成。此外,基于Nell1/EVs构建的3D-Nell1/EV-水凝胶系统,可实现EVs在骨缺损区域缓慢、持续释放和高浓度保存,有...
b Sequence alignments between miR-361-3p, miR-615-5p or miR-330-3p, and the seed sequence of circRNA 100146. WT and Mut represent wild-type and mutant sequences of circRNA. c Results of the dual-luciferase reporter gene assay in HEK-293 T cells. d, f Western blot of NFAT5, COL...