目的检测miR-362-5p在人舌鳞状细胞癌(TSCC)组织及细胞系中的表达,探讨miR-362-5p对TSCC细胞增殖和侵袭能力的影响,及其可能的作用机制.方法利用实时定量聚合酶链反应(PCR)技术检测TSCC组织及细胞系中miR-362-5p的表达水平;将miR-362-5p mimic,antagomiR-362-5p和阴性对照组分别转入人TSCC细胞SCC-9和UMl中,采用...
ration,cellcycleprogressionandtumorgrowth.Moreover,growtharrest-speci c7(GAS7) wascon rmedasadirecttargetgeneo miR-362-5pandwasnegativelymodulatedbymiR-362-5p.GAS7overexpression imitatedthetumorsuppressivee ecto silencedmiR-362-5ponTHP-1cells.Furthermore,miR-362-5pknockdownor GAS7overexpressionobviously...
表达miRNA.结果 在LUSC患者中发现了6种差异表达的血清miRNAs(miR-17-5p,miR-205-5p,miR-362-5p,miR-21-5p,miR-210-3p,miR-222-3p).其中miR-17-5p,miR-362-5p,miR-21-5p可以良好地区分LUSC组和对照组,受试者操作特征(ROC)曲线下面积(AUC)均>0.8(P0.8(P<0.001).TCGA数据库的数据显示,miR-17-5p或...
miR-362-5pbreastcancercells,miRNA-362-5p(miR-362-5p)ourknowledge,breastcancerhaveyetbeenreported.proliferation,migrationbreastcancercells.Therefore,presentresultssuggestpotentialmedicalvaluemiR-362-5p/CYLDaxiseffectivebreastcancertherapy.DownregulationmiR‑362‑5pinhibits proliferation, migration humanbreast ...
Recently, miR-362-5p has attracted special interest as a novel prognostic predictor in acute myeloid leukemia (AML). However, its biological function and underlying molecular mechanism in AML remain to be further defined. Herein, we found that a significant increase in miR-362-5p expression was ...
MicroRNA transcriptomes of distinct human NK cell populations identify miR-362-5p as an essential regulator of NK cell function Fang Ni1,2*, Chuang Guo1*, Rui Sun1, Binqing Fu1,3, Yue Yang2, Lele Wu2, Sitong Ren2, Zhigang Tian1,3 & Haiming Wei1 1Institute of Immunology and the ...
miR-362-5pMotilityProliferationNeuroblastomaPhosphatidylinositol 3-kinasemiR‐362‐5p is down‐regulated in high‐risk neuroblastoma and can function as a tumor suppressor. However, its role remains poorly understood. We show that miR‐362‐5p is down‐regulated in metastatic neuroblastoma compared with ...
Downregulation of miR- 362-5p inhibits proliferation, migration and invasion of human breast cancer MCF7 cells. Oncol Lett. 2016;11(2):1155-60... ML Wang,JL Niu,Y Gao,... 被引量: 0发表: 2018年 miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Met...
The expression of miR-362-5p was altered in THP-1 and HL-60 cells by transfecting with miR-362-5p mimic or inhibitor. A series of experiments showed that inhibition of miR-362-5p expression significantly suppressed cell proliferation, induced G0/G1 phase arrest and attenuated tumor growth in...
Furthermore study suggested that GADD45伪 mediated downstream the effects of miR-362-5p, which might indirectly regulates the activation of the JNK1/2 and P38 signalling pathways. Conclusion:miR-362-5p acts as an oncomiR that down-regulates GADD45伪, which consequently activates the JNK1/2 and...