产品活性:hsa-miR-372-5p mimic 是一种化学合成的miRNA模拟物,能模拟内源性miRNA,上调miRNA活性,用于功能获得性(gain-of-function)研究。 研究领域:Epigenetics 作用靶点:MicroRNA 相关产品:hsa-miR-4728-3p agomir | hsa-miR-126-3p agomir | rno-miR-6323 antagomir | mmu-miR-6395 inhibitor | hsa-miR-...
结果结直肠癌组织中miR-372-5p较癌旁组织表达升高,相对于NCM460,HCT116较SW620中miR-372-5p表达上调更显著(P<0.01);双荧光素酶实验证实PTEN是miR-372-5p的潜在靶基因(P<0.05).相较于NC组,miR-mimics可降低PTEN蛋白表达水平,增加CXCL12蛋白表达水平和AKT磷酸化水平,提高HCT116迁移能力;而miR-inhibitor则导致...
目的 检测急性脑梗死患者的血清miR-182-5p,miR-372-3p表达水平,并探讨其与患者病情及预后的关系.方法 选取2020年3月至2022年10月安阳市人民医院神经内科收治的136例急性脑梗死患者纳入脑梗死组,另选取本院同期136例体检健康志愿者作为对照组.根据病情程度将脑梗死组患者分为轻度组(n=42),中度组(n=59)和重度组...
如图5,转染miR-17-5p的模拟物和抑制物,流式细胞凋亡检测结果显示,过表达miR-17-5p可增加iTreg细胞凋亡(P=0.035),而抑制miR-17-5p可以减少iTreg细胞的凋亡(P=0.001)。 七. miR-17-5p对iTreg细胞增殖的影响 如图6所示,转染miR-...
研究结果表明在大鼠腺垂体中高表达且阶段性表达的lncRNA-m18as1促进FshβmRNA的表达与FSH的分泌。进一步的分子机制研究表明lncRNA-m18as1竞争性结合miR-18a-5p调控Smad2蛋白的表达,进而调控FSH的合成与分泌。 关键词组: 长链非编码...
产品活性:hsa-miR-372-5p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链,全链进行甲氧基修饰,在5'端和3'端分别有2个和4个硫代骨架修饰,并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA,阻止miRNA与其靶基因的互补配对,从而抑制miRNA的功能。相比于miRNA inhibitor,miRNA ant...
In conclusion, the results indicated that FER1L4 could inhibit the expression of miR-106a-5p/miR-372-5p, to activate E2F1-mediated NF-魏B pathway, leading to drug resistance in liver cancer.doi:10.1016/j.omtn.2021.02.006Xu WangYunfei Chen...
We checked the expression of various miRNAs which can target the 3'UTR of PCNA. Specifically, MEHP can decrease the expression of miR-27b-5p and miR-372-5p, which can directly bind with the 3'UTR of PCNA to inhibit its expression. Over expression of miR-27b-5p and miR-372-5p can ...
Hsa-miR-372-5p, as well as other differential expressed miRNA, might serve as potential targets in the therapy of various EBV associated diseases.doi:10.1080/10428194.2021.1933472Qi ChenShenglin LiuKaoyuan ZhangBo YuWei ZhangHongyu ZhangXiaofan Chen...
To sum up, this investigation primarily revealed miR-497-5p/FASN axis in CC, by which potential CC biomarkers, could be developed. However, the mechanism of the axis was not determined in vivo, as one of the study limitations.doi:10.1080/01635581.2022.2036351Haiyan Z...