(95%CI:0.74-0.97);肺癌细胞株A549转染外源性miR-367-3p后,细胞增殖,迁移能力显著降低(P<0.05);生物信息预测miR-367-3p下游靶基因为ZEB2,上调miR-367-3p表达后,ZEB2基因表达水平降低(P<0.05).癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据分析ZEB2表达水平与NSCLC患者预后关系显示,ZEB2高表达组NSCLC患者总...
与miR-NC组相比,miR-367-3p组WT-circ-TLK1荧光素酶相对活性显著降低(P<0.001),MUT-circ-TLK1荧光素酶相对活性无明显改变;与IgG组相比,Ago2组miR-367-3p和circ-TLK1的富集水平均显著升高(P<0.001),表明miR-367-3p可通过结...
Furthermore, the rescue experiments showed that the inhibition of miR-367-3p or the expression of MYO1B partially rescue the inhibition effects of SNHG4 in glioma cells. Our study reveals that SNHG4 promotes the proliferation, migration of glioma via regulating miR-367-3p/MYO1B axis....
目的 探究长链非编码RNA(lncRNA)MEG8通过调控miR-367-3p/磷酸酶张力蛋白同源物基因(PTEN)介导慢性阻塞性肺疾病(COPD)发展的分子机制.方法 采用实时荧光定量聚合酶链反应(qPCR)检测16HBE细胞和COPD组织lncRNA MEG8表达水平;在香烟烟雾提取物(CSE)刺激后的16HBE细胞中过表达lncRNA MEG8及加入miR-367-3p inhibitor后...
Methods: relative levels of miR-371a-3p, miR-373-3p and miR-367-3p were evaluated in serum of metastatic TGCC patients. A prospectively included and a retrospectively selected cohort were studied (total patient number = 109). Blood samples were drawn at start of chemotherapy and during follow...
目的探讨miR-367-3p调控细胞周期素D2重组蛋白(CCND2)表达对肺癌细胞增殖,迁移的影响.方法选取人肺癌细胞Calu,MSTO-211H,NCI-H2347,NCI-H1437,NCI-H1944,NCI-H647,人正常肺细胞HLF-a,qRT-PCR法测定细胞中miR-367-3p表达水平;将Calu细胞分为对照组,miR-367-3p NC组,miR-367-3p mimic组,miR-367-3p ...
miR-367-3p expression in DU145 and PC3 cells was also downregulated compared with that in the human prostate epithelial cell line RWPE-1. The overexpression of miR-367-3p or the knockdown of Rab23 inhibited the proliferation, invasion, and metastasis of prostate cancer cells. The results of ...
The roles of miR-302a-5p and miR-367-3p in the regulation of HMGA2 during the progression of endometrial cancer were investigated using both in vitro and in vivo assays. In the present study, high HMGA2 expression was correlated with poor clinical outcomes in endometrial cancer. The binding...
miRNA是一种存在于真核生物细胞中的一类内源性非编码的RNA小分子,miR-331-3p作为miRNA家族中的一员,在细胞生理过程中发挥重要作用.近年来,miR-331-3p在恶性肿瘤中的作用日益受到关注.已有研究显示,miR-331-3p在宫颈癌,肝癌,胶质母细胞瘤及前列腺癌等恶性肿瘤的发生发展及复发转移过程中均发挥着重要作用.这些研究...
在干细胞中表达丰富度较高;功能富集分析发现, hsa-miR-367-3p的靶基因涉及心室发育,转录调节等38个生物过程(P < 0.05),富集在神经元等21个细胞组分( P < 0.05).结论 hsa-miR-367-3p个别预测出来的靶基因与通路已经被证实,更多的预测结果需要进一步的研究加以验证.本研究为将来验证hsa-miR-367-3p的靶基因和...