肿瘤生长目的:研究miR-367-3p在非小细胞肺癌(non-small cell lung cancer,NSCLC)中促进肿瘤生长的作用机制.方法:收集非小细胞肺癌患者的临床标本,检测miR-367-3p在非小细胞肺癌组织中的表达.利用qRT-PCR,MrTT和流式细胞术分别评估miR-367-3p的表达改变对肿瘤细胞增殖和周期的影响.Western blot检测miR-367-3p表达...
与miR-NC组相比,miR-367-3p组WT-circ-TLK1荧光素酶相对活性显著降低(P<0.001),MUT-circ-TLK1荧光素酶相对活性无明显改变;与IgG组相比,Ago2组miR-367-3p和circ-TLK1的富集水平均显著升高(P<0.001),表明miR-367-3p可通过结...
miR-367-3p suppresses the proliferation,invasion and apoptosis of HL-60 cells by targeting RGS17 引用 收藏 分享 摘要 目的探讨微小RNA367-3p(miR-367-3p)对白血病细胞HL-60增殖、侵袭和凋亡的作用及相关机制。方法采用LipofectamineTM3000将miR-367-3p mimic、mim...展开更多 Objective To investigate the ...
Several studies have shown that miR-367-3p can function so as to promote or suppress the development of many forms of cancer, but its specific role in gastric cancer (GC) is not fully characterized. In this study, we found that patient GC samples exhibited significantly elevated miR-367-3p...
In this study, we show that miR-367-3p could enhance Sorafenib chemotherapy efficacyviaaltering MDM2-AR-(pAKT and pERK) signals and formed a positive feedback loop to better suppress the metastasis of hepatocellular carcinoma. Successful clinical application of these findings in the future may ...
Objective To predict target genes of hsa-miR-367-3p using bioinformatics tools and to determine pathways that hsa-miR-367- 3p might regulate. Methods Online databases like,miRGator v3.0,TargetScan,miRDB,and DAVID were used to predict and analyze the functions of hsa-miR-367-3p....
Methods: relative levels of miR-371a-3p, miR-373-3p and miR-367-3p were evaluated in serum of metastatic TGCC patients. A prospectively included and a retrospectively selected cohort were studied (total patient number = 109). Blood samples were drawn at start of chemotherapy and during follow...
miRNA是一种存在于真核生物细胞中的一类内源性非编码的RNA小分子,miR-331-3p作为miRNA家族中的一员,在细胞生理过程中发挥重要作用.近年来,miR-331-3p在恶性肿瘤中的作用日益受到关注.已有研究显示,miR-331-3p在宫颈癌,肝癌,胶质母细胞瘤及前列腺癌等恶性肿瘤的发生发展及复发转移过程中均发挥着重要作用.这些研究...
Conclusions MiR-107 and miR-99a-3p were validated as predictors of response to standard fluoropyrimidine-based chemotherapy in patients with mCRC. 展开 关键词: MicroRNAs Advanced colorectal cancer Chemotherapy response Prediction DOI: 10.1186/1471-2407-14-656 ...
miR-367-3pThe androgen receptor (AR) was found to suppress hepatocellular carcinoma (HCC) metastasis at late stages. Due to this discovery, we searched for some AR enhancers to increase the efficacy of Sorafenib chemotherapy, and identified the microRNA (miR)-367-3p, whose expression is ...