ASTROCYTESNEUROGLIAMICROGLIANEUROINFLAMMATIONNeuroinflammation is one of the postulated mechanisms for Pb neurotoxicity. However, the exact molecular mechanisms responsible for its pro-inflammatory effect are not fully elucidated. In this study, we examined the role of glial cells in neuroinflam...
phagocytosis, reducing microglial-mediated neuroinflammation, inhibiting microglial exosome synthesis and secretion, and promoting microglial conversion into a protective phenotype are considered to be promising strategies for the therapy of neurodegenerative diseases. Here we comprehensively review the biology of ...
Our understanding of diverse glial contributions to neurological diseases can lead advances in glial biology and their functional recovery after CNS malfunction. 展开 关键词: Alzheimer disease Astrocytes Astrocytoma CNS FTLD Microglia Neurodegeneration Neuroinflammation ...
Neuroinflammation induced by the peptide amyloid-β (25–35) increase the presence of galectin-3 in astrocytes and microglia and impairs spatial memoryEleazar Ramírez aClaudia Sánchez-Maldonado aMiguel A. Mayoral cLiliana Mendieta aVictorino Alatriste b...
l‐DOPA‐induced dyskinesia in Parkinson's disease: Are neuroinflammation and astrocytes key elements? Del-Bel E, Bortolanza M, Dos-Santos-Pereira M,ei al.L-DOPA-in-duced dyskinesia in Parkinson’s disease: Are neuroinflammationand astrocytes key ... E Del‐Bel,M Bortolanza,M Dos‐Santos...
PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation Co-inhibitory signaling controls immune mechanisms in health and disease. The authors here show that in autoimmune neuroinflammation, astrocytic PD-L1 mitigates autoimmune neuroinflamma...
Background:It has been demonstrated that reactive astrocytes can be polarized into pro-inflammatory A1 phenotype or anti-inflammatory A2 phenotype under ne... Y Hwang,HC Kim,EJ Shin - 《Journal of Neuroinflammation》 被引量: 0发表: 2022年 Astrocyte-microglia interaction in the expression of a ...
Microglia and astrocytes participate in uptake and phagocytosis of ISF Aβ [24, 25]. We investigated the effect of AQP4 deletion on these processes in APP/PS1 mice. AQP4−/−/APP/PS1 mice exhibited more Aβ aggregation within the cytoplasm of Iba1-positive microglia than APP/PS1 mice (...
WJ Streit,RE Mrak,WST Griffin - 《Journal of Neuroinflammation》 被引量: 911发表: 2004年 The immune system and developmental programming of brain and behavior Similarly, alterations in hormones, such as during stress, can powerfully impact immune function or reactivity. These functional shifts are...
Mitochondrial complex I activity in microglia sustains neuroinflammation Article Open access 13 March 2024 Mouse primary microglia respond differently to LPS and poly(I:C) in vitro Article Open access 17 May 2021 Metabolic flexibility ensures proper neuronal network function in moderate neuroinflammat...