This review discusses patents of several pharmaceutical compounds with actions on microglial cells which have the aim of controlling neuroinflammation. Some patents are about new pharmaceutical compounds that are not in clinical use while others propose new applications for drugs already use in clinical ...
We specifically focus on microglia as major players in neuroinflammation and discuss the spatial and temporal variations in microglial phenotypes that are observed under different conditions. We also consider how these cells could be modulated as a therapeutic strategy for AD. Key points Neuroinflammation...
cells in the inflammation process of AD.Microglia can be activated by β-amyloid protein,this activation can cause further release of pro-inflammatory cytokines and toxicmediators that might induce inflammatory responses in AD patients′brain and might contribute to neuronal injury and death.On the ...
cells and structures in local contextual settings,continuously patrol brain parenchyma utilizing their highly mobile fine processes,phagocytize protein aggregates,unwanted synapses and cells to maintain CNS health,and secrete neurotrophic factors to support neuronal function (Colonna and Butovsky,2017;Paoli...
Microglial cells as innate immune key players have a critical and unique role in neurodegenerative disorders. They strongly interact with their microenviro... Collmann, Franziska M.Pijnenburg, RorySchneider, GabrieleSchaefer, CordulaFolz-Donahue, KatKukat, ChristianHoehn, Mathias - 《Journal of Land ...
Expansion of SFA is important during microglial cell activation, but either supplemental SFA or MUFA may contribute to chronic low-grade neuroinflammation. 展开 关键词: BV2 microglial cells Matrix metalloproteinase 9 SHSY-5Y neuronal cells Bystander cell death Proteolytic activity Apoptosis Necrosis ...
Further mechanistic studies demonstrated that curcumin inhibited neuroinflammation by suppressing NF-κB and MAPK signaling pathways in Pam3CSK4-activated microglial cells. The results of the present study suggest that curcumin may be a novel treatment for neuroinflammation-mediated neurodegenerative disorders...
Neuroinflammation has been suggested to contribute to neurogenic hypertension. Microglia, the resident immune cells in the CNS, are the major source of proinflammatory cytokines (PIC). We and others have shown microglial activation and elevated activity of the renin-angiotensin system (RAS) in the ...
cells (Pickard and Chari, 2010). Although excess iron can directly produce toxic effects on neurons according to the classical oxidative stress pattern, it is believed microglia are one of the prime mediators and transgressors of neurotoxicity induced by ROS (Block et al., 2007; Pisanic et a...
Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor genetically linked to the risk for Alzheimer’s disease (AD). A proteolytic product, soluble TREM2 (sTREM2), is abundant in the cerebrospinal fluid and its levels positively correlate with neuronal injury ma...