Activation of microglia and neuroinflammation has been demonstrated in various neurodegenerative diseases as well as other pathologies of the brain. The present study aimed to investigate the role of microglial activation and neuroinflammation in acrylamide neurotoxicity. Male 10-week-old Wistar rats were ...
大会特邀主讲嘉宾Brian MacVicar教授作主旨演讲“Microglia and oxidative stress in neuroinflammation and neurodegeneration”,报告介绍了其团队开发的新型活性氧探针,首次发现了小胶质细胞在产生活性氧并影响神经元活性的直接证据。Brian MacVicar...
Microglia are resident macrophage-like immune cells in the central nervous system (CNS) and play a vital role in both physiological and pathological conditions, including restoring the integrity of the CNS and promoting the progression of neurodegenerative disorders. Upon stimulation, microglia typically ...
Neuroinflammation in Schizophrenia-Related Psychosis: A PET Study It is suggested that neuroinflammation plays a role in the pathophysiology of schizophrenia. Neuroinflammation is characterized by the activation of microglia ... J Doorduin,EFJ De Vries,ATM Willemsen,... - 《Journal of Nuclear ...
Innate Immunity and Neuroinflammation in the CNS. The Role of Microglia in Toll-Like Receptor-M
Innate Immunity and Neuroinflammation in the CNS: The Role of Microglia in Toll-Like Receptor-Mediated Neuronal Injury 小胶质细胞是中枢神经系统内的内源性免疫细胞,在中枢神经系统的固有免疫反应中扮演关键的角色,其主要作用是早期控制感染及激活适应性免疫系统细胞,以清除病原体.小胶... S Lehnardt - 《神...
They respond to perturbation of homeostasis by migration; proliferation; and production of cytokines, chemokines, and inflammatory mediators and they may have cytotoxic capability. Activated microglia are phagocytic and are implicated in clearance of debris in circumstances of neuroinflammation and ...
Glioblastoma (GB) is a highly invasive type of brain cancer exhibiting poor prognosis. As such, its microenvironment plays a crucial role in its progression. Among the brain stromal cells, the microglia were shown to facilitate GB invasion and immunosuppression. However, the reciprocal mechanisms by...
Recent researches also points out that changes in the gut microbiota would lead to a systemic inflammation that in different ways would reach the CNS modulating inflammatory pathways and especially the microglia, which could influence responses to treatments. Moreover, pre- and probiotics have shown ...
Microglia, the resident phagocytes of the central nervous system, play a major role in the non-autonomous clearance of protein aggregates. Their function is significantly altered by aging and neurodegeneration. This is genetically supported by the association of microglia-specific genes,TREM2andCD33,...