Activated microglia might have diverse influences on the progression of AD, depending on the stage of disease, individual susceptibility and state of microglial priming. Microglia could potentially be modulated at various points in the AD trajectory to either prevent or modify disease progression. This...
Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progressiondoi:10.3389/fimmu.2023.1305933NUCLEAR factor E2 related factorNF-kappa BDRUG side effectsALZHEIMER'S diseaseNEUROINFLAMMATION...
2022年9月21日,中山大学孙逸仙纪念医院神经科、脑科学研究中心唐亚梅教授领导的研究团队在Journal of Neuroinflammation上发表了题为“Pregabalinmitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiation-induced brain injury”的研究论文,阐明了普瑞巴林(Pregabalin)在RIBI中抑制...
2022年10月04日,温州医科大学附属第二医院/浙江省骨科重点实验室倪文飞和周凯亮团队在Journal of Neuroinflammation发表了综述“Emerging role of STING signalling in CNS injury: infammation, autophagy, necroptosis, ferroptosis and pyroptosis”,第一作者为胡新力(Xinli Hu)博士和张豪杰(Haojie Zhang)硕士,通讯作者...
2022年9月21日,中山大学孙逸仙纪念医院神经科、脑科学研究中心唐亚梅教授领导的研究团队在Journal of Neuroinflammation上发表了题为“Pregabalinmitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiat...
Microglial activation is a hallmark of neuroinflammation, seen in most acute and chronic neuropsychiatricconditions. With growing knowledge about microglia functions in surveying the brain foralterations, microglial activation is increasingly discussed in the context of disease progression andpathogenesis of Alz...
2022年10月04日,温州医科大学附属第二医院/浙江省骨科重点实验室倪文飞和周凯亮团队在Journal of Neuroinflammation发表了综述“Emerging role of STING signalling in CNS injury: infammation, autophagy, necroptosis, ferroptosis and pyroptosi...
and clearly defined the term “neuroinflammation,” which was guided by four primary features of peripheral inflammation: macrophage (microglial) activation, increased cytokines and chemokines, recruitment of peripheral immune cells, and local tissue damage [25,27]. These studies also demonstrated that ...
Neuroinflammation is mediated by two non-neuronal cell types in the brain, namely microglia and astroglia. Microglial activation and the resulting neuroinflammation have been implicated in a variety of neurological disorders including neurodegenerative diseases such as Alzheimer's disease (AD) and ...
3. Stinear, C. M.; Lang, C. E.; Zeiler, S.; Byblow, W. D., Advances and challenges in stroke rehabilitation.The Lancet. Neurology2020,19(4), 348-360. 4. Zhao, S. C.; Ma, L. S.; Chu, Z. H.; Xu, H.; Wu, W. Q.; Liu, F., Regulation of microglial activation in...