Subarachnoid hemorrhage, Inflammation, Microglia, Secondary brain injury, Inflammatory preconditioning, CSF1-ReceptorBackground Microglia-driven cerebral spreading inflammation is a key contributor to secondary brain injury after SAH. Genetic depletion or deactivation of microglia has been shown to ameliorate ...
Cleveland Clinic Genome Center researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer's disease. The study, published in the journal Alzheimer's ... Dec 6, 2024 0 37 Diseases, Conditions, Syndromes New hypothesis ...
GM1 decreased inflammatory microglia responses in vitro and in vivo, even when administered after microglia activation. These anti-inflammatory effects depended on the presence of the sialic acid residue in the GM1 glycan headgroup and the presence of a lipid tail. Other gangliosides shared similar ...
RESEARCH Open AccessMicroglia as target for anti-inflammatoryapproaches to prevent secondary braininjury after subarachnoid hemorrhage(SAH)Rebecca Heinz 1 , Susan Brandenburg 1 , Melina Nieminen-Kelhä 1 , Irina Kremenetskaia 1 , Philipp Boehm-Sturm 2,3 ,Peter Vajkoczy 1,2,4 and Ulf C. Schne...
Under pathological conditions, the activation of microglia helps in restoring CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Thus, negative regulators of microglial activation have been considered as ...
marker genes that are related to macrophage properties in vivo and in vitro showed a mixed picture that could mean that Gpnmb acts either unspecifically on all macrophages or creates a polarity of macrophages that is distinct from the known M1/M2 paradigm, as was reported for microglia45. ...
TRIM21-dependent ultrasmall chiral gold nanoparticles for preventing microglia senescence against Alzheimer’s disease Meiru Lu Changlong Hao Maozhong Sun Science China Chemistry (2024) The Evolving Applications of Bispecific Antibodies: Reaping the Harvest of Early Sowing and Planting New Seeds Diego...
Given that anti-inflammatory signaling is associated with tissue repair, understanding the signaling mechanisms downstream of Trem2 in coordinating the pro- and anti-inflammatory balance of microglia, particularly mediating effects of the IL-4-regulated anti-inflammatory pathway, has important implications ...
Undoubtedly, neuroinflammation is a major contributor to Alzheimer’s disease (AD) progression. Neuroinflammation is characterized by the activity of brain resident glial cells, in particular microglia, but also by peripheral immune cells, which infiltrate the brain at certain stages of disease progressio...
Fig. 1: Collaborative functions of EPCs and blood cells for vascular regeneration. This figure illustrates the hierarchical differentiation of endothelial progenitor cells (EPCs) and collaborative interactions in promoting vascular regeneration. It highlights the roles of EPCs in endothelial repair and their...