Genetic depletion or deactivation of microglia has been shown to ameliorate neuronal cell death. Therefore, clinically feasible anti-inflammatory approaches counteracting microglia accumulation or activation are interesting targets for SAH treatment. Here, we tested two different methods of interference with ...
Microglia, the resident macrophage cells in brain, are considered to play the key role in regulating neurotoxicity mediated by inflammatory response 2, 3. Microglial activation can be induced by lipopolysaccharide (LPS), interferon (IFN)-γ or β-amyloid in vitro (4). Activated microglia could ...
GM1 decreased inflammatory microglia responses in vitro and in vivo, even when administered after microglia activation. These anti-inflammatory effects depended on the presence of the sialic acid residue in the GM1 glycan headgroup and the presence of a lipid tail. Other gangliosides shared similar ...
Taken together, the results of the present study demonstrate that tangeretin possesses a potent anti-inflammatory and antioxidant effect in microglia. 展开 关键词: Tangeretin Microglia Anti-inflammation Antioxidant MMP Molecular mechanism DOI: 10.1007/s11481-016-9657-x ...
RESEARCH Open AccessMicroglia as target for anti-inflammatoryapproaches to prevent secondary braininjury after subarachnoid hemorrhage(SAH)Rebecca Heinz 1 , Susan Brandenburg 1 , Melina Nieminen-Kelhä 1 , Irina Kremenetskaia 1 , Philipp Boehm-Sturm 2,3 ,Peter Vajkoczy 1,2,4 and Ulf C. Schne...
By immunofluorescence, Elisa technique, western blot, scanning electron microscope (SEM) methods, we investigated the pro- and/or anti-inflammatory responses of microglia in the graphene films (2D-graphene) or graphene foams (3D-graphene) culturing systems. Furthermore, the growth situations of the...
Microglial cells play critical roles in the immune and inflammatory responses of the central nervous system (CNS). Under pathological conditions, the activation of microglia helps in restoring CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of various...
3D,E). The extracellular fragment of Gpnmb in the supernatant was measured at 48 h; here a different picture was observed: most of Gpnmb protein was shed by inflammatory M1 macrophages whereas reparative M2c macrophages showed reduced Gpnmb shedding (Fig. 3F). Thus, the macrophages with the ...
This chimeric fusion protein (αAβ–Gas6) selectively eliminates Aβ plaques through TAM receptor-dependent phagocytosis without inducing NF-kB-mediated inflammatory responses or reactive gliosis. Furthermore, αAβ–Gas6 can induce synergistic clearance of Aβ by activating both microglial and ...
Given that anti-inflammatory signaling is associated with tissue repair, understanding the signaling mechanisms downstream of Trem2 in coordinating the pro- and anti-inflammatory balance of microglia, particularly mediating effects of the IL-4-regulated anti-inflammatory pathway, has important implications ...