microglial activation and neuroinflammation constitute important features of MSA.283,284,285,286,287Histopathologically, microglial activation was found to be prominent in regions of motor-related structures
Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation. Biochim Biophys Acta. 2016;1862(3):339-51.Kaminska B, Mota M, Pizzi M. Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation. Biochim ...
during reperfusion in the infarcted heart in vivo17,18. However, the role of mitochondrial complexes in perpetuating the activation of microglia in the context of smouldering inflammatory central nervous system (CNS) diseases remains largely unexplored. To investigate the molecular mechanisms through which...
Microglia activation is recognized as the hallmark of neuroinflammation. However, the activation profile and phenotype changes of microglia during the process of retinal degeneration are poorly understood. This study aimed to elucidate the time-spatial pattern of microglia distribution and characterize the ...
However, the activation of microglia in the cerebellar region of the rats was not obvious during the whole observation period; although the microglia cells in the cerebellar region of MSCs treated rats showed a slightly stronger activation state in the early period (day 1), and the activation ...
70 Moreover, α-syn selectively suppresses Rac1 activation, leading to abnormal cytoskeletal rearrangements in SH-SY5Y neuronal cells.71 In light of this, PD-associated alteration in Rac1 activity may likely impact the formation and functionality of TNTs. TNTs facilitate α-syn transfer from ...
Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease. Inflammopharmacology. 2019;27(4):663–77. Article PubMed Google Scholar Kohl A, Dehghani F, Korf HW, Hailer NP. The bisphosphonate clodronate depletes microglial cells in excitotoxically injured ...
Neuroinflammation and microglial activation in Alzheimer disease: Where do we go from here? Nat Rev Neurol. 2020;17(3):157–72. Article PubMed Google Scholar Aguzzi A, Barres B, Bennett M. Microglia: scapegoat, sobateur, or something else? Science (80-). 2013;339(6116):156–61. ...
Mitochondrial complex I activity in microglia sustains neuroinflammation Article Open access 13 March 2024 Mouse primary microglia respond differently to LPS and poly(I:C) in vitro Article Open access 17 May 2021 Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux...
Together, we found that acute microglia ablation induces a type 1 interferon activation state of gray matter microglia associated with acute neurodegeneration.Similar content being viewed by others RhoA balances microglial reactivity and survival during neuroinflammation Article Open access 20 October 2023 ...