In Alzheimer's disease (AD), the brain's primary immune cells microglia become activated and are found in close apposition to amyloid beta (Aβ) protein plaques and neurofibrillary tangles (NFT). The present study evaluated microglia density and morphology in a large group of aged chimpanzees (...
INPP5D regulates inflammasome activation in human microglia INPP5D/SHIP1 is a microglial-expressed gene that has been associated with Alzheimer’s disease through genetic studies. This study reveals that reduction in INPP5D activity induces activation of the NLRP3-inflammasome in human microglia. ...
Brain aging is central to late-onset Alzheimer's disease (LOAD), although the mechanisms by which it occurs at protein or cellular levels are not fully understood. Alzheimer's disease is the most common proteopathy and is characterized by two unique pathologies: senile plaques and neurofibrillary...
Gordon S. Mitchell ResearchOpen Access28 Nov 2024Nature Communications Volume: 15, P: 10349 Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer’s disease mice by controlling astrocyte activation ...
Inflammation in Alzheimer Disease—A Brief Review of the Basic Science and Clinical Literature Biochemical and neuropathological studies of brains from individuals with Alzheimer disease (AD) provide clear evidence for an activation of inflammatory p... T Wyss-Coray,J Rogers - 《Cold Spring Harbor...
Microglia are activated by inflammation in the central nervous system, which may be triggered by neurological degenerative disorders such as Alzheimer disease or by infectious diseases such as Creutzfeldt-Jakob disease. Research suggests that microglia can help delay the progression of diseases in the ...
These cells could act by modulation of either the hydrolysis of the precursor protein during amyloidogenesis or the resorption of amyloid fibrils, which could occur in Alzheimer's disease as suggested by recent data. Further research on this topic could have therapeutical repercussions. 展开 ...
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Diagram of the brain of a person with Alzheimer's Disease. Credit: Wikipedia/public domain. For the first time, researchers have determined how toxic tau fibrils spread by the help of brain immune cells called microglia during the early stages of Alzheimer's disease (AD). The discovery of th...
Alzheimer’s disease (AD) is a multi-factorial neurodegenerative disease that is the most common cause of dementia and has evolved into one of the biggest challenges of modern medicine. Patients with AD suffer from a progressive decline in memory, performance disorders, behavior and personality chan...