The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stages, clarifying previous contradictory findings. ...
参考资料: [1] Chen, X., Firulyova, M., Manis, M. et al. Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature (2023). https://doi.org/10.1038/s41586-023-05788-0 [2]Discovery of T...
In individuals with Alzheimer's disease autosomal dominant, the excessive buildup of A尾 may stimulate the aberrant phosphorylation of tau, leading to its separation from microtubules. Tau subsequently associated into insoluble structure called helical filaments which further aggregate form neurofibrillary ...
However, some experts urge caution. "The role of microglia in the complex process of dementia is still somewhat confusing," said Belgian biologist Bart De Strooper, an expert in Alzheimer's disease, according to La Nación. "What is less clear is what changes cause neurodegeneration and which ...
Early detection and clinical diagnosis of Alzheimer’s disease (AD) have become an extremely important link in the prevention and treatment of AD. Bec
Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of Alzheimer’s disease (AD). However, the mechanism underlying this activity was unexplored. Here we show that N-acetyl s
widely adopted in microglial research, and the 2010s saw a boom of papers phenotyping macrophages and microglia into “M1” and “M2” based on the expression of markers related to these categories, used to indirectly assume a detrimental (“M1”) or beneficial (“M2”) microglial role.156...
Microglia, the resident immune cells of the brain, regulate neuroinflammation which can lead to secondary neuronal damage and cognitive impairment under pa
and hormonal factors which actively contribute to the differential incidences, disease courses, and even outcomes of CNS diseases between sexes. Microglia, as principle resident macrophages in the CNS, play a crucial role in both CNS physiology and pathology. However, sex differences of microglia hav...
Instead, we propose that persistent activation of microglia over a period of more than several weeks plays an important role in enhanced synapse remodeling. Synapse formation and elimination are believed to be the basis for the plastic changes of neuronal circuits [40, 41]. Therefore changes in ...