Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a crucial role in Alzheimer's disease (AD) pathogenesis, as revealed by genome-wide association studies (GWAS). Since then, ra
In addition, TREM2 is also involved in regulating inflammatory response and cell signaling pathways, affecting the immune response and regulatory role of microglia. Although the relationship between TREM2 and Alzheimer's disease has been extensively studied, its specific mechanism of action is not ...
Alzheimer’s disease (AD) and dementia in general are age-related diseases with multiple contributing factors, including brain inflammation. Microglia, and specifically those expressing the AD risk gene TREM2, are considered important players in AD, but their exact contribution to pathology remains unc...
Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microglia reactivity to AD pathology. Given the he...
Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microg
Molecular Neurodegeneration (2022) 17:84 https://doi.org/10.1186/s13024-022-00588-y REVIEW Open Access TREM2 dependent and independent functions of microglia in Alzheimer's disease Jinchao Hou1, Yun Chen1,2, Gary Grajales‑Reyes1 and Marco Colonna1* Abstract ...
摘要 阿尔茨海默病（Alzheimer's disease，AD）常见于老年人，临床表现为记忆力减退、精神行为异常等。1. 首都医科大学附 AD 的发病机制目前尚不清楚，目前存在的多种假说并不能完全解释 AD 的全部发病特征。小胶质细胞是脑 属北京安定医院，组织中特殊的巨噬细胞，可监测周围神经元和胶质细胞的健康情况，同时具有...
The discovery of TREM2 as a myeloid-specific Alzheimer’s disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal and disease-associated functions of TREM2 in human microglia remain unclear. To examine...
In the brain, TREM2 is located predominantly on microglia and is highly expressed in white-matter regions [22]. TREM2 activity is linked to a variety of diseases that display white matter-pathology such as Nasu-Hakola disease (NHD), frontotemporal lobar degeneration (FTLD), and multiple scleros...
The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore. 来自 学术范 喜欢 0 阅读量: 12 作者:C Gussago,M Casati,E Ferri,B Arosio ...