The editorial "Microglia in neurodegenerative diseases" published in Frontiers in Cellular Neuroscience discusses the role of microglia in neurodegenerative diseases such as Parkinson's, Alzheimer's, and ALS. Microglia, as resident immune cells of the central nervous system, play a crucial r...
generative Diseases Microglia in Neurodegenerative DiseasesMicroglia in Neurodegenerative Diseasesミクログリア神経変性疾患アルツハイマー病筋萎縮性側索硬化症Microglia activation plays a crucial role in neurodegenerative diseases. There are at least two distinct ways of microglia activation, the classical ...
and promoting microglial conversion into a protective phenotype are considered to be promising strategies for the therapy of neurodegenerative diseases. Here we comprehensively review the biology of microglia and the roles of microglia in neurodegenerative diseases, including Alzheimer’s ...
exacerbates disease progression. Systemic inflammation is associated with a decline in function in patients with chronic neurodegenerative disease, both acutely and in the long term. The fact that diseases with a chronic systemic inflammatory component are risk factors for Alzheimer disease implies that c...
Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. Evidence from postmortem analysis implicates the involvement of microglia in the neurodegenerative process of several degenerative neurological diseases, i... B Liu,JS Hong - 《Journal...
26 The homeostatic equilibrium of microglial cells is disrupted when pattern recognition receptors are activated by pathological protein aggregates, such as α-syn or tau, in neurodegenerative diseases.27 These sterile immune stimuli may drive disease progression by releasing a multitude of immune ...
Inflammation plays a critical role in the progression of neurodegenerative diseases. Microglia are the resident macrophages of the central nervous system (CNS) which actively take part in the neuronal development of CNS and are involved in clearance of pathogens as well as cellular debris from the ...
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases Immunity, 47 (2017), pp. 566-581.e9 View in ScopusGoogle Scholar La Joie et al., 2020 R. La Joie, A.V. Visani, S.L. Baker, J.A. Brown, V. Bourakova, J. Cha, K. ...
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets Article Open access 22 September 2023 Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? Article 14 December 2020 Roles and regulation of microglia activity in multiple sclerosis...
In humans, mutations in genes expressed in microglia are linked to various neurodegenerative diseases. Here we provide an overview of the common microglial response to neurodegeneration and key contributing pathways; delineate the multifaceted functions of activated microglia spanning various diseases; and ...