Furthermore, mast cell depletion led to an upregulation of transcriptomic signatures for putatively protective disease-associated microglia and resulted in reduced markers indicative of reactive astrocytes. We hypothesize a system of bidirectional communication between dural mast cells and the brain, where ...
Microglia: neuroprotective and neurotrophic cells in the central nervous system. Microglia are currently accepted as sensor cells in the central nervous system that respond to injury and brain disease.The main function of microglia is b... K Nakajima,S Kohsaka - 《Current Drug Targets Cardiovascular...
We quantified the expression level of 31 RNA transcripts that could collectively identify (1) OPC and OL-lineage states, including resting MOL subtypes and DAO states; (2) homeostatic microglia and DAMs; (3) homeostatic astrocytes and DAAs; (4) endothelial cells; and (5) neurons (Figure 4A)...
Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury Spp1表达的命运图谱揭示脑损伤后疾病相关小胶质细胞样细胞的年龄依赖性可塑性 相关领域 小胶质细胞 生物 神经科学 先天免疫系统 突触修剪 神经可塑性 免疫系统 神经炎症 炎症 免疫学 ...
Because disease-associated microglia (DAM) and disease-associated astrocytes (DAA) are involved in the pathophysiology of Alzheimer's disease (AD), we systematically identified molecular networks between DAM and DAA to uncover novel therapeutic targets for AD. Specifically, we develop a network-based ...
Dysregulated microglial response is a hallmark of AD21,22, and the candidates showing expression-driven dependency in the hematopoietic and lymphoid tissue analysis may present targets whose intervention may only affect disease-associated microglia (DAM). For example, SPI1 (PU.1) is a transcription ...
1b. c, Disease associated microglia (DAM) signature enriched in AD. Violin plots showing the distribution in WT (n=8 animals, 896 cells) and AD (n=8 animals, 1,540 cells) of microglia expression scores for signatures of genes up-regulated in DAM compared to homeostatic microglia (from ...
Deletion of Slc9a1 in Cx3cr1+ cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk Shanshan Song Helena Oft Dandan Sun Journal of Neuroinflammation (2024) SRT-Server: powering the analysis of spatial transcriptomic data Sheng Yang Xiang Zhou Genome Medicine...
Tsilioni, I. and Theoharides, T.C. (2018). Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β.J. Neuroinflammation15: 239,https://doi.org/10.1186/s12974-018-1275-5.Search in...
Microglia represent innate immune cells of the CNS that play important disease-modifying roles in neurodegeneration including Alzheimer’s disease (AD) [1,2,3,4]. The importance of microglia-mediated neuroinflammation in neurodegeneration has been confirmed by genetic studies that identified several immun...