disease-associated microgliamicrogliaTDP-43TREM2Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is an aggressive motor neuron degenerative disease characterized by selective loss of both upper and lower motor neurons. The mechanisms underlying disease initiation and progression ...
在分子水平上,高通量单细胞RNA测序(single-cell RNA-sequencing, scRNA-seq)分析研究表明,根据转录组表达水平的差异,小胶质细胞对淀粉样蛋白斑块做出的反应使其活化形成4类功能各异的细胞群,即疾病相关的(disease-associated microglia, DAM)...
The general consensus is that TREM2 is essential for inducing transcriptomic and functional processes in disease-associated microglia (DAMs), a subtype of microglia that occur in the brain in various animal models of neurodegeneration, characterized by the activation of pathways related to phagocytosis ...
Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimers disease,Science Translational Medicine(2019). [2]TREM2-Dependent Effects on Microglia in Alzheimers Disease.Front Aging Neurosci. (2018). [3]medicalxpress.com/news/...
Microglia that adhere to Aβ plaques acquire a transcriptional signature, "disease-associated microglia" (DAM), which largely emanates from the TREM2-DAP12 receptor complex that transmits intracellular signals through the protein tyrosine kinase SYK. The human TREM2R47H variant associated with high ...
018-1148-y REVIEW TREM2 regulates innate immunity in Alzheimer's disease Jiang-Tao Li and Ying Zhang* Open Access Abstract Recent research has shown that the triggering receptor expressed on myeloid cells 2 (TREM2) in microglia is closely related to the pathogenesis of Alzheimer's disease (AD...
Triggering receptor expressed on myeloid cell 2 (TREM2) is linked to risk of neurodegenerative disease. However, the function of TREM2 in neurodegeneration is still not fully understood. Here, we investigated the role of microglial TREM2 in TAR DNA-binding protein 43 (TDP-43)-related neurodegene...
Furthermore, non-coding LOAD risk variants are largely confined to microglia-specific enhancer regions of the genome [3]. “Disease-associated” microglia have been identified in multiple mouse neurodegenerative disease models, which have a common transcriptional signature that is largely dependent on ...
TREM2 is a transmembrane protein expressed exclusively in microglia in the brain that regulates inflammatory responses to pathological conditions. Proteolytic cleavage of membrane TREM2 affects microglial function and is associated with ... R Dhandapani,M Neri,M Bernhard,... 被引量: 0发表: 2021年 ...
Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice. mAbs, 2022. doi.org/10.1080/1942086 10. Gratuze, M., Leyns, C. E. G., & Holtzman, D. M. New insights into the role of TREM2 in Alzheimer's disease. Molecular ...