protein processing, autophagy, neurodegeneration, and lysosomal function (Fig.1F). Interestingly, in both the CAG-correlated and multi-region disease-associated gene sets, KEGG pathways involved in inflammation, cancer-related pathways, and lipid metabolism were also significantly enriched (Fig.1F, G)....
Huttenrauch, M.; Ogorek, I.; Klafki, H.; Otto, M.; Stadelmann, C.; Weggen, S.; Wiltfang, J.; Wirths, O. Glycoprotein NMB: A novel Alzheimer's disease associated marker expressed in a subset of activated microglia. Acta Neuropathol. Commun. 2018, 6, 108. [CrossRef] [PubMed]...
No morphological features were conclusively associated with loss or gain of any of the markers or any of the identified phenotypes. All in all, none of the three markers were expressed by all microglia, nor can be wholly regarded as a pan- or homeostatic marker, and preferential phenotypes ...
Dot plot showing the expression level (color scale) and the percent of cells expressing (dot size) marker genes across all clusters (rows). Cluster numbers as in Fig. 1b. c, Disease associated microglia (DAM) signature enriched in AD. Violin plots showing the distribution in WT (n=8 ...
Microglia, macrophages that live in the brain, have an excellent, phagocytic function and can clear Aβ in the healthy state of the body. Under pathological conditions, the function of microglia in phagocytosing Aβ is weakened, and overexpressed Aβ and microglia activate the microglial inflammat...
More importantly, clearance of Aβ may be improved by activation of microglia [24, 25]. In the present study, Aβ-positive products, and CD68, a phagocyte-associated marker [22], are detected in cell bodies of activated microglia in the frontal cortex of AQP4−/−/APP/PS1 mice. ...
III—Levels of key cerebellar neurochemicals are intrinsically associated to motor behaviour in transgenic MJD mice (Tg-ATXN-3-69Q model) Next, linear regressions between the rotarod and levels of five main altered cerebellar neurometabolites in MJD mice (NAA, NAA + NAAG, Glu, Tau, and ...
In our present study, we performed immunofluorescence staining of the SN region to detect the activation of glial cells, using GFAP as the marker of astrocytes, and Iba-1 as the marker of microglia. Both GFAP+ and Iba-1+ cells showed significant elevation in the SN region of the rotenone ...
In a recent study by Kim et al., the loss of B cells benefited AD patients by reducing Aβ plaque burden and disease-associated microglia, reversing behavioral and memory deficits and restoring TGFβ + microglia50. To clarify the causes of the disagreement between our results and theirs,...
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