Altered motility of plaque-associated microglia in a model of Alzheimer’’s disease. Gyoneva S,Swanger SA,Zhang J,et al. Neuroscience . 2016Gyoneva, S., Swanger, S. A., Zhang, J., Weinshenker, D., and Traynelis, S. F. (2016). Altered motility of plaque-associated microglia in ...
The role of microglia cells in Alzheimer’s disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4+) and non-containing (XO4−) microglia from an AD mouse model. Tra...
microgliaperipheral immune cellsplaque‐associated myeloid cellsAlzheimer's disease (AD) is the leading cause of age‐related neurodegeneration and is characterized neuropathologically by the accumulation of insoluble beta‐amyloid (Aβ) peptides. In AD brains, plaque‐associated myeloid (PAM) cells ...
THE EFFECT OF CHRONIC ANTI-INFLAMMATORY DRUG USE ON SENILE PLAQUES AND PLAQUE-ASSOCIATED MICROGLIAcerebral oedemaoperationintravenous fluidsHamartomatous proliferations of genital smooth muscle are uncommon and may be easily overlooked if the normal microscopic appearance of the scrotal dartos is unf...
The up-regulation of IDO occurred in the activated microglia in amyloid plaques and was associated with a 5-fold elevation of brain QUIN. We also found that level of picolinic acid, another tryptophan metabolite able to antagonize QUIN, was not affected. Neuronal expression of IDO in Tg2576 ...
1998 . Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease ... Fusheng Yang, Xiaoyan Sun, Walter Beech, Bruce Teter, et al - 《American Journal of Pathology》 被引量: 0发表: 1998年 L-type voltage...
(2840 cm−1) including two main categories; lamellar structures (e.g.in a, e and g) and coalescent structures of different sizes, possibly originating from lipid micelles initially decorating the Aβ fibrils or ApoE particles, alternatively from lipid microvesicles shedded by microglia (see ...
Supplementary information for Impairment of in vivo calcium signaling in amyloid plaque- associated microglia Bianca Brawek1, Bernd Schwendele1, Karin Riester1, Shinichi Kohsaka2, Chommanad Lerdkrai1, Yajie Liang1, Olga Garaschuk1, * Corresponding author: Olga Garaschuk; Institute of Physiol...
Identifying approaches to specifically target plaque-associated microglia (PAMs) without interfering in the homeostatic functions of non-plaque associated microglia would afford a powerful tool and potential therapeutic avenue. Methods: Here, we demonstrated that a systemically administered nanomedicine, ...
In AD, amyloid-b (Ab) plaque-associated microglia (PAM) display a clearly distinct phenotype compared to plaque-distant microglia (PCM), suggesting that these two microglia subtypes likely differently contribute to disease progression. Methods: In this study, we combined cell-specific laser capture ...