Altered motility of plaque-associated microglia in a model of Alzheimer’’s disease. Gyoneva S,Swanger SA,Zhang J,et al. Neuroscience . 2016Gyoneva, S., Swanger, S. A., Zhang, J., Weinshenker, D., and Traynelis, S. F. (2016). Altered motility of plaque-associated microglia in ...
. Similar to our bulk analyses of XO4+/−microglia, PC1 was dominated by the shift to a plaque-phagocytosing phenotype. We detected a substantial overlap of 344 DEGs (64.2% of single-cell gene expression signature associated with XO4+microglia,p = 3.35 × 10−34, hypergeometri...
To test whether we could alter plaque associated microglia phenotypes via peripheral drug administration, we next injected 5xFAD mice intraperitoneally with hydroxyl dendrimers conjugated to N゛cetyl cysteine, OP1, which has demonstrated ability to cause normalization of reactive microglia in several animal...
THE EFFECT OF CHRONIC ANTI-INFLAMMATORY DRUG USE ON SENILE PLAQUES AND PLAQUE-ASSOCIATED MICROGLIAcerebral oedemaoperationintravenous fluidsHamartomatous proliferations of genital smooth muscle are uncommon and may be easily overlooked if the normal microscopic appearance of the scrotal dartos is unf...
microgliaperipheral immune cellsplaque‐associated myeloid cellsAlzheimer's disease (AD) is the leading cause of age‐related neurodegeneration and is characterized neuropathologically by the accumulation of insoluble beta‐amyloid (Aβ) peptides. In AD brains, plaque‐associated myeloid (PAM) cells ...
The up-regulation of IDO occurred in the activated microglia in amyloid plaques and was associated with a 5-fold elevation of brain QUIN. We also found that level of picolinic acid, another tryptophan metabolite able to antagonize QUIN, was not affected. Neuronal expression of IDO in Tg2576 ...
-associated reactive astrocytes (ii; GFAP, red arrows), and not plaque associated reactive microglia (iii; IBA1, white arrows) or neurons (iv; MAP2, white arrows). Insert in ii shows a higher magnification image of the colocalization of ARL8B and GFAP in plaque associated astrocytes...
1998 . Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease ... Fusheng Yang, Xiaoyan Sun, Walter Beech, Bruce Teter, et al - 《American Journal of Pathology》 被引量: 0发表: 1998年 L-type voltage...
Cerebral injection of clodronate liposomes or adeno-associated virus (AAV) encoding apoE siRNAs Clodronate liposomes (Liposoma, Amsterdam, The Netherlands; #P22JO419) were injected into the frontal cortex to deplete local microglia, as previously reported [21]. Three-month-old APP/PS1 mice and AQP4...
Reductions in plaque load were accompanied by decreases in plaque number, GFAP-positive astrocytes, Iba1-positive microglia and phospho-tau positive neurons. Finally, S100B immunoreactivity in cortex and hippocampus of PSAPP mice was plaque associated and co-localized with astrocytes/microglia. These ...