Ting LiEspinosa-Oliva, MaríaFrontiers in Cellular NeurosciencePerry VH, Nicoll JA, Holmes C. Microglia in neurodegenerative disease. Nat Rev Neurol. 2010; 6: p. 193-201.
Holmes, "Microglia in neurodegenerative disease," Nature Reviews Neurology, vol. 6, no. 4, pp. 193-201, 2010.Perry VH, Nicoll JA, Holmes C. Microglia in neurodegenerative disease. Nat Rev Neurol. 2010;6:193-201.Perry VH, Nicoll JA, Holmes C. Microglia in neurodegenerative disease. Nat ...
12Recent advances in scRNA-seq and snRNA-seq technologies have identified high spatial and temporal heterogeneity levels and unique disease-related signatures of these reactive microglia without correspondence to the canonical M1/M2 classification in neurodegenerative diseases.13,14,15For...
exacerbates disease progression. Systemic inflammation is associated with a decline in function in patients with chronic neurodegenerative disease, both acutely and in the long term. The fact that diseases with a chronic systemic inflammatory component are risk factors for Alzheimer disease implies that c...
It is well accepted that CNS inflammation has a role in the progression of chronic neurodegenerative disease, although the mechanisms through which this oc... C Cunningham - 《Glia》 被引量: 430发表: 2013年 A Mechanism for Neurodegeneration Induced by Group B Streptococci through Activation of th...
M. Fakhoury, "Role of immunity and inflammation in the pathophysiology of neurodegenerative diseases," Neurodegener- ative Diseases, vol. 15, no. 2, pp... Marc,Fakhoury - 《Neurodegenerative Diseases》 被引量: 31发表: 2015年 Microglia-Mediated Inflammation and Neurodegenerative Disease Microglia-me...
Targeting microglial activation has proven to be a viable option in the treatment of inflammation related neurodegenerative diseases. This review will discuss the central position of inflammation and therapeutic strategies aiming to alleviate disease progression in some of the important inflammatory conditions...
26 The homeostatic equilibrium of microglial cells is disrupted when pattern recognition receptors are activated by pathological protein aggregates, such as α-syn or tau, in neurodegenerative diseases.27 These sterile immune stimuli may drive disease progression by releasing a multitude of immune ...
Table 1.Expression of risk genes of neurodegenerative disease in CNS. Based on[30,31]. One of the key functions of microglia is to eliminate debris through phagocytosis. Using specific recognition, engulfment, and degradation processes, microglia maintain brain homeostasis (reviewed in[32]) but in...
A host of new molecular tools and mouse models of disease are increasingly implicating this enigmatic type of nervous system cell as a key player in conditions ranging from neurodevelopmental disorders such as autism to neurodegenerative disorders such as Alzheimer's disease and chronic pain. ...