ASTROCYTESAstrocytes are abundant glial cells in the central nervous system (CNS) that play active roles in health and disease. Recent technologies have uncovered the functional heterogeneity of astrocytes and their extensive interactions with other cell types in the CNS. In this Review, we hi...
4 Astrocytes activate pro-inflammatory signaling in an LCN2-dependent manner, and SLC22A17 is required for astrocyte response to LCN2. a. Expression of SLC22A17 in bulk RNA-seq of different cell populations isolated from samples of human gliomas (CD45- n = 23, MG n = 21, ...
It is not known whether an AD-specific reactive astrogliosis signature is possible given the astroglial diversity and dynamic pathologies involved in AD. Nonetheless, it opens important novel avenues into understanding astrocyte reactivity in the context of persistent inflammation that may lead to ...
In this Review, we highlight how single-cell and single-nuclei RNA sequencing and other ‘omics’ technologies can enable the functional characterization of defined reactive astrocyte states in various pathological scenarios. We provide an integrated perspective, advocating cross-modal validation of key ...
An Evolutionary Perspective on Immunosenescence The choice between life and death is one of the major events in regulation of the immune system. T cells that specifically recognize viral or bacterial ant... C Franceschi,M Bonafè,S Valensin,... 被引量: 2409发表: 2000年 Karin, M. & Lin,...
In this Review, we highlight how single-cell and single-nuclei RNA sequencing and other 'omics' technologies can enable the functional characterization of defined reactive astrocyte states in various pathological scenarios. We provide an integrated perspective, advocating cross-modal validation of key ...
binding of excess CNS glutamate to induced lymphocytic mGluR1 receptors may contribute to an excess Th1 response, including IFN-γ. We further hypothesize that IFN-γ in a small quantity, similar to its in vitro effects on microglia, may induce microglial expression of MHC-II and EAAT-2, all...
Journal of Neuroinflammation BioMed Central Review Open Access The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective Solomon S Shaftel1, W Sue T Griffin2 and M Kerry O'Banion*1,3 Address: 1Department of Neurobiology and Anatomy, University of Rochester ...
Systemic inflammation and DAMPs after sterile injury The brain has long been referred to as an immune-privileged organ, although it is becoming more apparent that neuroimmune interactions between the periphery and the CNS are not rare or restricted to brain neuropathology22. The presence of a physic...
It would be interesting to determine if antibodies to Kir4.1, an inward-rectifying potassium channel co-localized with AQP4 on astrocyte foot processes are able to cause NMO- like disease. Does the Th cell have to be specific for AQP4 in order to induce AQP4-specific antibodies It is ...