The characterization of these subsets and the mechanisms that control them may provide unique insights into the pathogenesis of neurologic diseases, and identify potential targets for therapeutic intervention. In this article, we provide an overview of the role of astrocytes in CNS inflammation, ...
Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response. Each inflammasome complex has three major components: an upstream sensor molecule that is connected to a downstream effector protein such as caspase-1 through the ...
The role of astroglia in neuroprotection Astrocytes are the main neural cell type responsible for the maintenance of brain homeostasis. They form highly organized anatomical domains that are inter... M Bélanger,PJ Magistretti - 《Dialogues Clin Neurosci》...
Astrocytes, as a significant component of the blood–brain barrier, behave as one of the immune effecter cells in the CNS as well. However, both cell types may play a dual role, amplifying the effects of inflammation and mediating cellular damage as well as protecting the CNS. Interactions ...
Involvement of cytokines in normal CNS development and neurological diseases: recent progress and perspectives. J Neurosci Res 1998; 52: 7–16. Article CAS Google Scholar Allan SM, Rothwell NJ . Inflammation in central nervous system injury. Philos Trans R Soc Lond B Biol Sci 2003; 358: ...
Macrophages, regarded as the paramount immune cells in the body, are omnipresent from their inception to the culmination of disease progression and exert a significant influence on the pathophysiology of CNS inflammation, thereby precipitating neurodegenerative diseases. Despite the protective function of th...
The functional role of MPO in neutrophil-mediated destruction of bacteria has been ascribed to the fundamental studies of Klebanoff [11,12]. 1.1. Enzymes related to MPO MPO belongs to the peroxidase family of enzymes. As this review is focused solely on MPO, only a brief summary of other ...
Furthermore, we outline the inflammatory responses associated with such infections, and discuss the potential role of resident glial cells in the pathogenesis of bacterially induced CNS disorders. 展开 关键词: CNS, bacteria, inflammation, microglia, astrocytes ...
The blood–brain barrier, which is formed by the endothelial cells that line cerebral microvessels, has an important role in maintaining a precisely regulated microenvironment for reliable neuronal signalling. At present, there is great interest in the association of brain microvessels, astrocytes and...
for the ability of the immune system and abnormal immune function, including inflammation, cytokine dysregulation, and anti-brain autoantibodies, to act as a significant influence on ASD has prompted researchers to look more closely at the potential role of immune dysregulation and autoimmunity in ASD...