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A subtype of depression with clear-cut links to the peripheral immune system is the depression caused by intense peripheral inflammation10. In this form of depression, vigorous activation of the peripheral immune system, which can occur during infections or in diseases that induce systemic inflammation...
Astrocytes are the most abundant non-neuronal cell type in the central nervous system (CNS). They serve numerous critical functions in the brain, including regulation of synapse formation and pruning, as well as regulation of neuroinflammation and lactate and glutamate levels in the brain [1]. As...
Astrocyte Crosstalk in CNS Inflammation 2020, Neuron Show abstract Function and therapeutic value of astrocytes in neurological diseases 2022, Nature Reviews Drug Discovery Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes 2021, Nature Astrocytes contribute to remote memory...
The precise onset, temporal progression and spatial extent of neuron-tumor crosstalk in brain with Glioblastoma (GBM) are not fully understood. Here authors, using a genetic GBM mouse model, show widespread glutamate accumulation, chronic neural activity disruption between cells and brain areas, depend...
In addition, astrocyte responses to aging and neurodegeneration are likely affected by crosstalk with other cell types including neurons, microglia and oligodendrocytes (Palmer and Ousman, 2018). 2.3 Does astrocyte morphology change with aging? In response to CNS insults, besides changing their gene ...
6). Our studies reveal a previously unknown function of astrocytic TRPV1 and potentially identify a critical target for the treatment of CNS inflammation. Fig. 6 Schematic illustration of the proposed mechanism. TRPV1 plays an important role in neonatal HI-induced astrocytes activation and the ...
Astrocyte-Microglia Crosstalk: A Novel Target for the Treatment of Migraine Migraine is a pervasive neurologic disease closely related to neurogenic inflammation. The astrocytes and microglia in the central nervous system are vital... M Sun,J Rong,M Zhou,... - 《Aging & Disease》 被引量: 0发...
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