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Astrocyte Crosstalk in CNS Inflammation 2020, Neuron Citation Excerpt : CRISPR-Cas9-based inactivation of Sigmar1, Ern1 (encoding IRE1α), or Xbp1 in astrocytes, decreased pro-inflammatory gene expression in microglia and monocytes, suggesting that SigmaR1-IRE1α-XBP1 signaling modulates astrocyte-mi...
The precise onset, temporal progression and spatial extent of neuron-tumor crosstalk in brain with Glioblastoma (GBM) are not fully understood. Here authors, using a genetic GBM mouse model, show widespread glutamate accumulation, chronic neural activity disruption between cells and brain areas, depend...
6). Our studies reveal a previously unknown function of astrocytic TRPV1 and potentially identify a critical target for the treatment of CNS inflammation. Fig. 6 Schematic illustration of the proposed mechanism. TRPV1 plays an important role in neonatal HI-induced astrocytes activation and the ...
Liu, B., Hong, J.S.: Role of microglia in inflammation-mediated neurodegenerative diseases: mech- anisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 304, 1–7 (2003). doi:10. 1124/jpet.102.035048 62. Bruce-Keller, A.J.: Microglial–neuronal interactions in ...
Inflammation can cause endoplasmic reticulum (ER) stress and therefore activates the unfolded protein response (UPR). ER stress and the consequent UPR have the potential to activate NF-κB. However, the factors mediating the crosstalk between ER stress and the NF-κB pathway remain unclear. Here,...
Traumatic brain injury (TBI) is a disease with high mortality and morbidity, which leads to severe neurological dysfunction. Neurogenesis has provided therapeutic options for treating TBI. Brain derived neurotrophic factor (BDNF) plays a key role in neur
Astrocyte Crosstalk in CNS Inflammation 2020, Neuron Show abstract Function and therapeutic value of astrocytes in neurological diseases 2022, Nature Reviews Drug Discovery Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes 2021, Nature Astrocytes contribute to remote memory...
Endocytic BDNF secretion regulated by Vamp3 in astrocytes Article Open access 27 October 2021 Astrocyte–neuron crosstalk through extracellular vesicle-shuttled miRNA-382-5p promotes traumatic brain injury Article Open access 02 December 2024 Astrocyte Support for Oligodendrocyte Differentiation can be...