Disorders of the central nervous system (CNS), in particular those leading to cognitive deficits, are the main challenge facing medicine in the 21st century. Pathophysiologically based cures of CNS disorders do not yet exist; at best contemporary medicine is limited to symptomatic treatments. This ...
In CNS pathologies, reactive astrocytes represent a double-edged sword; on the one hand, they worsen the extent of injury due to the release of pro-apoptotic substances and Ca2+, while, on the other hand, they contribute to regenerative processes during the chronic phase of injury. The ...
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse functions in health and disease. Astrocyte dysfunction is found in numerous diseases, including multiple sclerosis, Alzheimer disease, Parkinson disease, Huntington disease and neuropsychiatric disorders. Astrocytes ...
glial cell,neurogliacyte,neuroglial cell- a cell of the neuroglia astroglia,macroglia- tissue consisting of large stellate neuroglial cells fibrous astrocyte- star-shaped cells with long processes; found in the white matter of the brain and spinal cord ...
Astrocytes belong to the 3 types of glial cells in the CNS (the others are microglia and oligodendrocytes). Astroglia is used as a synonym. These cell exhibt usually a star-shaped mmorphology, with many processes extending from the soma. Astrocytes can be identified histologically since they ...
Macrophage/microglia (M) are the principal immune cells in the central nervous system (CNS) concomitant with inflammatory brain disease and play a significant role in the host defense against invading microorganisms. Astrocytes, as a significant component of the blood–brain barrier, behave as one ...
We aimed to reproduce the peritumoral astrocytic conditions by introducing cGAMP directly into astrocytes and to quantify the metabolic changes around the glutamine (Gln)-glutamate (Glu) cycle, as major CNS metabolism. In cGAMP-treated cells, the synthetic flux of Gln from 13C5,15N-Glu was ...
Astrocytes control tissue equilibrium and hence define the homoeostasis and function of the CNS (central nervous system). Being principal homoeostatic cells, astroglia are fundamental for various forms of neuropathology, including AD (Alzheimer's disease). AD is a progressive neurodegenerative disorder ...
The synapses in the CNS are formed by three elements: by the pre- and postsynaptic neuronal compartments and by the astroglial perisynaptic processes. This structure is generally known as a tripartite synapse.66, 67 The neurotransmitters released in the course of synaptic transmission from the neuro...
Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta (Aβ) clearance. Alzheimer’s disease (AD)...