Peng, "Expression of GFAP, GLAST and GLT-1 in astrocytes in patients with mesial temporal lobe epilepsy," Journal of Hainan Medical University, vol. 22, no. 2, pp. 87-90, 2016.J. Lu, Q.-C. Zeng, Q. Wang, Y.-H. Huang, and Q. Peng, "Expres- sion of GFAP, GLAST and GLT-...
The glutamate transporter GLAST is localized on the cell membrane of mature astrocytes and is also expressed in the ventricular zone of developing brains. To characterize and follow the GLAST-expressing cells during development, we examined the mouse spinal cord by in situ hybridization and immunohisto...
The GLT-1 and GLAST glutamate transporters are expressed on morphologically distinct astrocytes and regulated by neuronal activity in primary hippocampal c... (2000). The GLT-1 and GLAST glutamate transporters are expressed on morphologically distinct astrocytes and regulated by neuronal activity in prim...
The protein is distributed in both grey matter astrocytes and radial glial cells, and in white matter where it is localized to oligodendrocytes. We have not excluded the possibility that the protein might also be expressed in white matter astrocytes because of the extent of staining in the white...
Important Notice: As a transmembrane protein, GLAST immunostaining displays punctate/reticular-like structures and is not suitable for outlining the shape of astrocytes in vivo, especially in adult animals. Immunogen: The intracellular fragment of rat GLAST fused to GST. Purification: Affinity purificat...
In rodent, GLAST is expressed on astrocytes mainly in cerebellum, but also in forebrain regions including cerebral cortex and hippocampus (Torres and Amara, 2007). Postmortem studies revealed no changes in expression of glutamate transporter GLAST in the striatum (McCullumsmith and Meador-Woodruff, ...
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Thus, long-term treatment with the group I mGluR agonist, DHPG, causes down-regulation of GLAST, whereas the group II agonist, DCG-IV, has an opposite effect on the expression of GLAST in astrocytes. However, in BT4C glioma cells glutamate or other transportable substrates (D-aspartate and ...
Effects of ammonia on glutamate transporter (GLAST) protein and mRNA in cultured rat cortical astrocytes Ammonia is a neurotoxic substance which accumulates in brain in liver failure and it has been suggested that ammonia plays a key role in contributing to th... H Chan,AS Hazell,P Desjardins,...
Clearance of glutamate from the extracellular space is accomplished primarily by the action of glutamate transpor- ters.9 In the CNS, the glutamate/aspartate transporter (GLAST) and glutamate transporter 1 (GLT-1) are Na þ -dependent glutamate transporters found in astrocytes. Genetic deletion of...