Astrocytes repress the neuronal expression of GLAST and GLT glutamate transporters in cultured hippocampal neurons from embryonic rats. Neurochem Int. 2004; 45 :1113–1123.Plachez C, Martin A, Guiramand J, Recasens M. 2004. Astrocytes repress the neuronal expression of GLAST and GLT glutamate ...
Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes 喜欢 0 阅读量: 14 摘要: Sept2 is a member of the septin family of GTPases. Septins form filaments in a GTP-form dependent manner, and are involved in cytokinesis from yeast to mammals; however, ...
The protein is distributed in both grey matter astrocytes and radial glial cells, and in white matter where it is localized to oligodendrocytes. We have not excluded the possibility that the protein might also be expressed in white matter astrocytes because of the extent of staining in the white...
Important Notice: As a transmembrane protein, GLAST immunostaining displays punctate/reticular-like structures and is not suitable for outlining the shape of astrocytes in vivo, especially in adult animals. Immunogen: The intracellular fragment of rat GLAST fused to GST. Purification: Affinity purificat...
In rodent, GLAST is expressed on astrocytes mainly in cerebellum, but also in forebrain regions including cerebral cortex and hippocampus (Torres and Amara, 2007). Postmortem studies revealed no changes in expression of glutamate transporter GLAST in the striatum (McCullumsmith and Meador-Woodruff, ...
Astrocytes are responsible for clearance of extracellular glutamate, primarily through glial-specific glutamate transporter-1 and the Na+-dependent glutama... YP Liu,CS Yang,MC Chen,... - 《Journal of Neurochemistry》 被引量: 53发表: 2010年 Glutamate signaling in bone Activation of ionotropic glu...
The findings documented that GLAST is expressed by Bergmann glia and by astrocytes throughout the CNS. The glial localization of GLAST mRNA was verified unequivocally by double-labeling with an astrocytic marker protein. Additionally, GLAST mRNA reactivity and GLAST immunoreactivity were found in ...
Here, using CreER T2 –LoxP recombination technology, we generated inducible and astrocyte﹕pecific GDNF conditional knockout (cKO), that is, GLAST〨DNF/ cKO mice to investigate the effect of reactive astrocytes (RAs)ヾerived GDNF on neuronal death, brain damage, oxidative stress and motor ...
Transporter , is Localized to Astrocytes and Gabaergic Neurons besides Pyramidal Cells in the Rat Cerebral Cortex High-affinity uptake of from the plays a crucial role in regulating neuronal activity in physiological and pathological conditions. We have used affinity-p... F Conti,S Debiasi,A Mine...
Clearance of glutamate from the extracellular space is accomplished primarily by the action of glutamate transpor- ters.9 In the CNS, the glutamate/aspartate transporter (GLAST) and glutamate transporter 1 (GLT-1) are Na þ -dependent glutamate transporters found in astrocytes. Genetic deletion of...